Dr. Garcia-Tsao is Professor of Medicine at Yale University School of Medicine. She has dedicated her professional life to the study of complications of cirrhosis through patient-oriented research. Since having been awarded the K-24 award she has continued to significantly contribute to the knowledge of cirrhosis, a significant cause of mortality in the productive years of life. The project proposed in the initial K-24 submission was successfully completed and resulted in a publication that has led to the recommendation of using large-volume paracentesis + albumin as standard of care in the treatment of refractory ascites. As a rational followup to this study, Dr. Garcia-Tsao has now received funding to evaluate the effect of a combination of vasoconstrictors ooctreotide+midodrine) as alternative to albumin after large-volume paracentesis. Another of the goals outlined in her original K-24 submission was to focus on prophylactic therapy and on the identification of prognostic factors in chronic liver disease. In this regard, Dr. Garcia-Tsao has importantly contributed to the completion of a long trial of beta-blocker in the prevention of varices and identified portal pressure as an important predictor of cirrhosis decompensation not only in all cirrhotic patients, but particularly in those with cirrhosis secondary to hepatitis C. As program director of one of four VA Hepatitis C Resource Centers (granted during the term of the K-24 award) she will apply this knowledge to studies of antiviral therapy in the prevention of cirrhosis decompensation. As Director of the recently funded Clinical Core of the Yale Liver Center she will continue to devote major efforts toward mentoring beginning clinical investigators in POR. Mentoring of junior faculty, postgraduate fellows, medical students in POR has almost doubled since obtaining the K-24 award. Renewal of the award will allow Dr. Garcia-Tsao to maintain both POR and her mentoring endeavors to their fullest extent so she can continue to make significant contributions in the field of chronic liver disease and its complications.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
2K24DK002727-06
Application #
6927777
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Podskalny, Judith M,
Project Start
1999-09-01
Project End
2010-03-31
Budget Start
2005-04-01
Budget End
2006-03-31
Support Year
6
Fiscal Year
2005
Total Cost
$153,187
Indirect Cost
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Jangouk, Parastoo; Turco, Laura; De Oliveira, Ana et al. (2017) Validating, deconstructing and refining Baveno criteria for ruling out high-risk varices in patients with compensated cirrhosis. Liver Int 37:1177-1183
Albillos, Agustín; Zamora, Javier; Martínez, Javier et al. (2017) Stratifying risk in the prevention of recurrent variceal hemorrhage: Results of an individual patient meta-analysis. Hepatology 66:1219-1231
Fortune, Brett; Garcia-Tsao, Guadalupe (2014) Current Management Strategies for Acute Esophageal Variceal Hemorrhage. Curr Hepatol Rep 13:35-42
Belcher, Justin M; Parikh, Chirag R; Garcia-Tsao, Guadalupe (2013) Acute kidney injury in patients with cirrhosis: perils and promise. Clin Gastroenterol Hepatol 11:1550-8
Tandon, Puneeta; Delisle, Angela; Topal, Jeffrey E et al. (2012) High prevalence of antibiotic-resistant bacterial infections among patients with cirrhosis at a US liver center. Clin Gastroenterol Hepatol 10:1291-8
Sethasine, Supatsri; Jain, Dhanpat; Groszmann, Roberto J et al. (2012) Quantitative histological-hemodynamic correlations in cirrhosis. Hepatology 55:1146-53
Bari, Khurram; Miñano, Cecilia; Shea, Martha et al. (2012) The combination of octreotide and midodrine is not superior to albumin in preventing recurrence of ascites after large-volume paracentesis. Clin Gastroenterol Hepatol 10:1169-75
Zipprich, Alexander; Garcia-Tsao, Guadalupe; Rogowski, Sebastian et al. (2012) Prognostic indicators of survival in patients with compensated and decompensated cirrhosis. Liver Int 32:1407-14
Berzigotti, Annalisa; Garcia-Tsao, Guadalupe; Bosch, Jaime et al. (2011) Obesity is an independent risk factor for clinical decompensation in patients with cirrhosis. Hepatology 54:555-61
Opio, Christopher Kenneth; Garcia-Tsao, Guadalupe (2011) Managing varices: drugs, bands, and shunts. Gastroenterol Clin North Am 40:561-79

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