Clinical research in pediatric disorders is essential to ensure advances in the management, prognosis and quality of life of infants, children and adolescents with these problems. The goals are (1) to foster a program in hypothesis-driven, expert clinical research in pediatric gastroenterology and nutrition, (2) to mentor young clinicians in pediatric gastroenterology and nutrition research, and (3) to promote ongoing interactions and collaborations with clinical investigators. To achieve these goals, current projects and future investigations of gastrointestinal and nutrition problems in pediatric patients will be conducted by trainees at various levels under the guidance and supervision of Dr. Heyman and his collaborators. Studies involving pediatric patients with inflammatory bowel disease (Crohn's disease and ulcerative colitis), HIV infection, familial adenomatous polyposis syndrome (with FAP gene mutations), ichthyosis erythrodermas with poor nutrition, and gastroesophageal reflux disease are currently ongoing or planned utilizing the facilities and staffs of the Pediatric Gastroenterology/Nutrition Clinics and the Pediatric Clinical Research Center at the University of California, San Francisco (UCSF). A cohort study is in the planning stage to determine whether nutrition advice promotes improved long-term outcomes in eating behaviors and health status (e.g., micronutrient adequacy; and growth parameters). The overriding objective of this proposal is to motivate and inspire young clinicians embarking on careers focused on clinically oriented research. Pediatric gastroenterology trainees will be instructed in the proper conduct of perspective randomized controlled clinical trials in infants, children, and adolescents. Trainees will also participate in didactic courses covering clinical trial design and procedure, protocol writing, data management, and ethical considerations. This award will enhance the applicant's ability to devote more time to research- related activities, and to provide guidance and instruction for trainees advancing towards productive scientific careers.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
1K24DK060617-01
Application #
6420040
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Podskalny, Judith M,
Project Start
2002-07-01
Project End
2007-06-30
Budget Start
2002-07-01
Budget End
2003-06-30
Support Year
1
Fiscal Year
2002
Total Cost
$128,846
Indirect Cost
Name
University of California San Francisco
Department
Pediatrics
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Lowe, Margaret M; Mold, Jeff E; Kanwar, Bittoo et al. (2014) Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production. PLoS One 9:e87877
Verstraete, Sofia G; Heyman, Melvin B; Wojcicki, Janet M (2014) Breastfeeding offers protection against obesity in children of recently immigrated Latina women. J Community Health 39:480-6
Winter, Harland S; Krzeski, Piotr; Heyman, Melvin B et al. (2014) High- and low-dose oral delayed-release mesalamine in children with mild-to-moderately active ulcerative colitis. J Pediatr Gastroenterol Nutr 59:767-72
Salazar, Guadalupe; Heyman, Melvin B (2014) Benefits of attending a summer camp for children with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 59:33-8
Salazar, Guadalupe; Barker, Judith C; Heyman, Melvin B (2013) Medical students' conceptualizations of quality of life associated with children with IBD. J Pediatr Gastroenterol Nutr 57:493-9
Wojcicki, Janet M; Geissler, Jillian D; Stokes, Christina W et al. (2013) The use of the RESPeRATE device to lower blood pressure in inner city obese adolescents and children: a pilot feasibility study. High Blood Press Cardiovasc Prev 20:89-92
Thaler, M Michael; Heyman, Melvin B (2013) Dedicated bibliometrics: a more appropriate impact factor for specialty journals? J Pediatr Gastroenterol Nutr 57:413
Zahir, N; Heyman, M B; Wojcicki, J M (2013) No association between childcare and obesity at age 4 in low-income Latino children. Pediatr Obes 8:e24-8
Courtier, Jesse; Ohliger, Michael; Rhee, Sue J et al. (2013) Shooting a moving target: use of real-time cine magnetic resonance imaging in assessment of the small bowel. J Pediatr Gastroenterol Nutr 57:426-31
Watson, Lisa C; Kuchenbecker, Kristopher M; Schiller, Benjamin J et al. (2013) The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals. Nat Struct Mol Biol 20:876-83

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