This competitive renewal application for a K24 award is to provide support as I (Paul R. Conlin) further my work in patient-oriented research and mentoring of junior investigators. My career has focused on studying mechanisms of blood pressure regulation and more recently, methodologies to improve diabetes care. My long-term goals remain focused on studying lifestyle modification strategies to reduce renal and cardiovascular disease risk factors in patients with hypertension and diabetes through clinical trials. Prior to and during the current award period, I was a co-investigator in three interventional nutrition studies that explored the effects of macro- and micronutrients on blood pressure. As a direct extension of these studies, I am now investigating the effects of the Dietary Approaches to Stop Hypertension (DASH) diet on renal and cardiovascular hemodynamics, to better understand the mechanisms by which the diet lowers blood pressure. In these studies, I am testing the hypothesis that the DASH diet has ACE inhibitor-like effects on renal blood flow, renal and vascular responsiveness to angiotensin II, vascular stiffness, and diastolic function. These studies are being conducted in patients with isolated systolic hypertension. I have also extended my clinical research program to include funded studies at our affiliated VA Medical Center, where I study care management strategies using information technology, to improve blood pressure and glucose control in patients with diabetes mellitus. As a direct result of the protected time afforded by this K24 award, I am mentoring 3 junior investigators (two of whom have career development awards), have accepted a new research fellow to join me in early 2007, and I co-mentor two other individuals. I have assumed a leadership role in the K30-funded "Scholars in Clinical Sciences Program" at Harvard Medical School, serving as Chair of the Mentoring Committee. During the new award period, I will continue with my funded research program and expand the scope of my mentoring, both directly and indirectly through the K30 program. I have a great passion for mentoring junior investigators destined for careers in patient-oriented research, particularly those interested in renal and cardiovascular physiology, interventional nutrition or diabetes care management. With the support of this award, I will make a significant impact on future patient-oriented researchers at multiple levels.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Rankin, Tracy L
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Brigham and Women's Hospital
United States
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Garg, Rajesh; Sun, Bei; Williams, Jonathan (2014) Effect of low salt diet on insulin resistance in salt-sensitive versus salt-resistant hypertension. Hypertension 64:1384-7
Kerfoot, B Price; Turchin, Alexander; Breydo, Eugene et al. (2014) An online spaced-education game among clinicians improves their patients' time to blood pressure control: a randomized controlled trial. Circ Cardiovasc Qual Outcomes 7:468-74
Goldfine, A B; Conlin, P R; Halperin, F et al. (2013) A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance. Diabetologia 56:714-23
Chamarthi, Bindu; Williams, Gordon H; Ricchiuti, Vincent et al. (2011) Inflammation and hypertension: the interplay of interleukin-6, dietary sodium, and the renin-angiotensin system in humans. Am J Hypertens 24:1143-8
Svetkey, Laura P; Harris, Emily L; Martin, Eden et al. (2011) Modulation of the BP response to diet by genes in the renin-angiotensin system and the adrenergic nervous system. Am J Hypertens 24:209-17
Cheng, Peiyao; Neugaard, Britta; Foulis, Philip et al. (2011) Hemoglobin A1c as a predictor of incident diabetes. Diabetes Care 34:610-5
Kerfoot, B Price; Lawler, Elizabeth V; Sokolovskaya, Galina et al. (2010) Durable improvements in prostate cancer screening from online spaced education a randomized controlled trial. Am J Prev Med 39:472-8
Garg, Rajesh; Hurwitz, Shelley; Williams, Gordon H et al. (2010) Aldosterone production and insulin resistance in healthy adults. J Clin Endocrinol Metab 95:1986-90
Furtado, Jeremy D; Campos, Hannia; Sumner, Anne E et al. (2010) Dietary interventions that lower lipoproteins containing apolipoprotein C-III are more effective in whites than in blacks: results of the OmniHeart trial. Am J Clin Nutr 92:714-22
Chamarthi, Bindu; Williams, Jonathan S; Williams, Gordon H (2010) A mechanism for salt-sensitive hypertension: abnormal dietary sodium-mediated vascular response to angiotensin-II. J Hypertens 28:1020-6

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