This is a competing renewal K24 application for Viola Vaccarino, MD, PhD. The primary objective is to continue and expand an already successful research and mentoring program in patient-oriented research in the area of behavioral cardiology and mind-body relationships in cardiovascular disease (CVD). The success of this program was due in large part to the previous K24 support. The applicant was able to assemble substantial funding and collaboration opportunities, and attract many junior investigators who have worked productively under her mentorship;several have established an independent academic career. In order continue and build upon this work the PI seeks five additional years of protected time. The applicant's research involves the study of social, behavioral, and psychological determinants of cardiovascular risk, and the underlying mechanisms linking these factors to CVD. Her recent investigations supported by the K24 have produced significant contributions on the role of depression on the outcome of men and women with CVD, the role of inflammation, metabolic syndrome and autonomic function as they relate to depression, and role of genetic influences. Her most recent work has pioneered the concept of a central role played by genetic background in the relationship between depression and CVD or CVD risk factors. The applicant needs protected time to continue this pi^omising area of investigation and obtain new research grants. A main objective of the Pi's career development is maintaining and strengthening her mentoring program. The path to become a successful academic investigator is difficult and insecure. Patient-oriented researchers, especially those with clinical responsibilities, face special challenge. A critical goal ofthe Pi's program is to facilitate the route to academic advancement for promising new patient-oriented investigators. The applicant has become an essential member of many training programs at Emory and is a highly sought- after mentor. She seeks to secure protected time for the next five years so that she can continue her mentoring activities and expand them to attract a larger number of beginning investigators. Ultimately, Dr. Vaccarino's career goal is to contribute significantly to the advancement of the science and the clinical applications in the area of bio-behavioral relationships in CVD, through outstanding research and the training ofthe next generation of investigators.

Public Health Relevance

In this renewal application for a K24 Mid-Career Investigator Award, the PI seeks protected time to continue and expand a successful research and training program on mind-body relationships in cardiovascular disease. Specific areas of interest are the social, behavioral, and psychological determinants of cardiovascular risk, and the underlying mechanisms. A key goal is to facilitate the path to academic advancement for promising new patient-oriented investigators through training and mentoring.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Special Emphasis Panel (ZHL1-CSR-R (M1))
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Stoney, Catherine
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Emory University
Public Health & Prev Medicine
Schools of Public Health
United States
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Vaccarino, Viola; Shah, Amit J; Rooks, Cherie et al. (2014) Sex differences in mental stress-induced myocardial ischemia in young survivors of an acute myocardial infarction. Psychosom Med 76:171-80
Wei, Jingkai; Rooks, Cherie; Ramadan, Ronnie et al. (2014) Meta-analysis of mental stress-induced myocardial ischemia and subsequent cardiac events in patients with coronary artery disease. Am J Cardiol 114:187-92
Vaccarino, Viola; Goldberg, Jack; Magruder, Kathryn M et al. (2014) Posttraumatic stress disorder and incidence of type-2 diabetes: a prospective twin study. J Psychiatr Res 56:158-64
Kulshreshtha, Ambar; Zheng, Yan; Quyyumi, Arshed A et al. (2014) Endothelial Dysfunction is Associated with Occult Coronary Artery Disease Detected by Positron Emission Tomography. IJC Metab Endocr 4:28-32
Goldberg, Jack; Magruder, Kathryn M; Forsberg, Christopher W et al. (2014) The association of PTSD with physical and mental health functioning and disability (VA Cooperative Study #569: the course and consequences of posttraumatic stress disorder in Vietnam-era veteran twins). Qual Life Res 23:1579-91
Goetz, Margarethe; Shah, Amit; Goldberg, Jack et al. (2014) Posttraumatic stress disorder, combat exposure, and carotid intima-media thickness in male twins. Am J Epidemiol 180:989-96
Shah, Amit J; Ghasemzadeh, Nima; Zaragoza-Macias, Elisa et al. (2014) Sex and age differences in the association of depression with obstructive coronary artery disease and adverse cardiovascular events. J Am Heart Assoc 3:e000741
Kulshreshtha, Ambar; Goyal, Abhinav; Veledar, Emir et al. (2014) Association between ideal cardiovascular health and carotid intima-media thickness: a twin study. J Am Heart Assoc 3:e000282
Wei, Jingkai; Pimple, Pratik; Shah, Amit J et al. (2014) Depressive symptoms are associated with mental stress-induced myocardial ischemia after acute myocardial infarction. PLoS One 9:e102986
Plantinga, Laura; Bremner, J Douglas; Miller, Andrew H et al. (2013) Association between posttraumatic stress disorder and inflammation: a twin study. Brain Behav Immun 30:125-32

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