The scientific goal of this proposal is to investigate the effects of relative growth hormone deficiency and replacement on body composition and cardiovascular risk markers in men and women with abdominal obesity. The career development goal of this application is to support the candidate's professional development as a clinical investigator and successful mentor for fellows and junior faculty in patient-oriented clinical research by providing sufficient time for research and mentoring activities. The mentoring goal of this application is to facilitate the training of fellows and junior faculty in clinical research to form the basis of independent careers. The candidate's NHLBI-funded R01 grant investigating the effects of growth hormone replacement on body composition and cardiovascular risk markers in viscerally adipose men and women with relative growth hormone deficiency will form the basis for the training plan of the grant. Additional research opportunities are available in the form of ongoing studies that are funded by a number of other sources. The candidate has a record of leadership in mentoring on a national level and a successful track record of mentoring trainees in the Massachusetts General Hospital (MGH) Endocrine Fellowship program and other disciplines. The Institutional environment at the MGH, with a strong and diverse Medicine Department, Clinical Translational Science Center grant through Harvard Medical School, and Clinical Research Program, is outstanding. The Department of Medicine at the MGH has made a substantial commitment, including 90% protected time and dedicated space, toward the candidate's development as a clinical researcher responsible for training fellows and junior faculty. The Midcareer Investigator Award in Patient Oriented Research is an ideal mechanism to ensure the necessary support to reduce clinical and administrative responsibilities, and ensure the candidate's continued success as a mentor and clinical researcher.

Public Health Relevance

Cardiovascular disease is the leading cause of death and illness in developed countries. This proposal investigates the role of low growth hormone levels as a possible hormone mechanism underlying the increased cardiovascular risk in women and men with abdominal adiposity and thus could have significant public health implications.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Special Emphasis Panel (ZHL1-CSR-R (F1))
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Aviles-Santa, Larissa
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Massachusetts General Hospital
United States
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Dichtel, Laura E; Lawson, Elizabeth A; Schorr, Melanie et al. (2017) Neuroactive Steroids and Affective Symptoms in Women Across the Weight Spectrum. Neuropsychopharmacology :
Bachmann, Katherine N; Schorr, Melanie; Bruno, Alexander G et al. (2017) Vertebral Volumetric Bone Density and Strength Are Impaired in Women With Low-Weight and Atypical Anorexia Nervosa. J Clin Endocrinol Metab 102:57-68
Bredella, Miriam A; Karastergiou, Kalypso; Bos, Stijn A et al. (2017) GH administration decreases subcutaneous abdominal adipocyte size in men with abdominal obesity. Growth Horm IGF Res 35:17-20
Schorr, Melanie; Thomas, Jennifer J; Eddy, Kamryn T et al. (2017) Bone density, body composition, and psychopathology of anorexia nervosa spectrum disorders in DSM-IV vs DSM-5. Int J Eat Disord 50:343-351
Dichtel, Laura E; Corey, Kathleen E; Misdraji, Joseph et al. (2017) The Association Between IGF-1 Levels and the Histologic Severity of Nonalcoholic Fatty Liver Disease. Clin Transl Gastroenterol 8:e217
Dichtel, Laura E; Schorr, Melanie; Gill, Corey M et al. (2017) Body composition in pituitary, adrenal and iatrogenic Cushing's syndrome and effects of DHEAS levels. Clin Endocrinol (Oxf) 86:160-162
Bachmann, Katherine N; Bruno, Alexander G; Bredella, Miriam A et al. (2016) Vertebral Strength and Estimated Fracture Risk Across the BMI Spectrum in Women. J Bone Miner Res 31:281-8
Karastergiou, Kalypso; Bredella, Miriam A; Lee, Mi-Jeong et al. (2016) Growth hormone receptor expression in human gluteal versus abdominal subcutaneous adipose tissue: Association with body shape. Obesity (Silver Spring) 24:1090-1096
Fazeli, Pouneh K; Teoh, Jonathan G; Lam, Eleanor L et al. (2016) Effect of growth hormone treatment on diastolic function in patients who have developed growth hormone deficiency after definitive treatment of acromegaly. Growth Horm IGF Res 26:17-23
Bove, Riley M; Gerweck, Anu V; Mancuso, Sarah M et al. (2016) Association between adiposity and cognitive function in young men: Hormonal mechanisms. Obesity (Silver Spring) 24:954-61

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