Obsessive compulsive disorder (OCD) is a severe, prevalent and chronically disabling disorder that often emerges during childhood. Nonetheless, pediatric OCD remains an understudied disorder. One reason is that there are too few researchers with sufficient skills and understanding in both developmental neurobiology and neuropsychopharmacology. Treatment studies using biological markers as moderator (present at baseline) and mediator (changing with treatment) may potentially lead to a mechanistic understanding of the pathogenesis and maintenance of the illness, which may in turn result in the development of new diagnostic and treatment approaches. This is critical because at least one third of patients do not respond at all, even after apparently adequate treatment trials. Treatment-refractory patients are also more likely to have early onset of illness. Preliminary studies suggest a reversible glutamatergically mediated thalamocortical-striatal dysfunction in OCD that may serve as a pathophysiological and treatment response marker. In this context, the candidate's chief aim is to use time liberated by the K24 Award to develop, evaluate and disseminate biological outcome markers of OCD and determine their relevance for improved diagnostic assessment and treatment. To this end, the K24 career development plan (1 )furthers the candidate's knowledge in clinical neuroscience emphasizing the integration and translation of brain imaging measurement as it relates to neurodiagnostic assessment and treatment, 2) furthers the candidates knowledge in the conduct and design of relevant clinical trials for treatment development, and (3) emphasizes knowledge dissemination of the translational components of this research, including a proposed T32 training grant focused on psychopathology and treatment of pediatric mental disorders. The K24 research plan centers on ongoing and proposed treatment outcome studies using brain imaging to help elucidate neurobiological markers in childhood OCD. The K24 will advance sustained practical and theoretical contributions to the candidates chosen research area.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24MH002037-04
Application #
6732172
Study Section
Special Emphasis Panel (ZRG1-BBBP-6 (01))
Program Officer
Wagner, Ann
Project Start
2001-05-01
Project End
2006-04-30
Budget Start
2004-05-01
Budget End
2005-04-30
Support Year
4
Fiscal Year
2004
Total Cost
$130,123
Indirect Cost
Name
Wayne State University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
001962224
City
Detroit
State
MI
Country
United States
Zip Code
48202
Wu, Ke; Hanna, Gregory L; Easter, Philip et al. (2013) Glutamate system genes and brain volume alterations in pediatric obsessive-compulsive disorder: a preliminary study. Psychiatry Res 211:214-20
Fallucca, Erin; MacMaster, Frank P; Haddad, Joseph et al. (2011) Distinguishing between major depressive disorder and obsessive-compulsive disorder in children by measuring regional cortical thickness. Arch Gen Psychiatry 68:527-33
MacMaster, Frank P; Rosenberg, David R (2010) THE USE OF GLUTAMATE MODULATING DRUGS IN OBSESSIVE COMPULSIVE DISORDER. Child Adolesc Psychopharmacol News 15:1-5
Macmaster, Frank P; Rosenberg, David R (2010) Glutamate and the Treatment of Obsessive-Compulsive Disorder. Psychopharm Rev 45:33-40
MacMaster, Frank P; Rosenberg, David R (2010) NEUROBIOLOGICAL EVIDENCE SUPPORTING GLUTAMATE'S ROLE IN PEDIATRIC OBSESSIVE COMPULSIVE DISORDER. Child Adolesc Psychopharmacol News 15:6-10
Macmaster, Frank; Vora, Anvi; Easter, Phillip et al. (2010) Orbital frontal cortex in treatment-naïve pediatric obsessive-compulsive disorder. Psychiatry Res 181:97-100
Arnold, Paul Daniel; Macmaster, Frank P; Hanna, Gregory L et al. (2009) Glutamate system genes associated with ventral prefrontal and thalamic volume in pediatric obsessive-compulsive disorder. Brain Imaging Behav 3:64-76
Arnold, Paul Daniel; Macmaster, Frank P; Richter, Margaret A et al. (2009) Glutamate receptor gene (GRIN2B) associated with reduced anterior cingulate glutamatergic concentration in pediatric obsessive-compulsive disorder. Psychiatry Res 172:136-9
Chen, Hua-Hsuan; Rosenberg, David R; MacMaster, Frank P et al. (2008) Orbitofrontal cortex volumes in medication naive children with major depressive disorder: a magnetic resonance imaging study. J Child Adolesc Psychopharmacol 18:551-6
MacMaster, Frank P; O'Neill, Joseph; Rosenberg, David R (2008) Brain imaging in pediatric obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry 47:1262-72

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