This is a competing renewal application for a K24 Career Award in Patient-Oriented Research. The candidate, Dr. David Steffens, is Professor of Psychiatry and Medicine at Duke University Medical Center, where he serves as the Head of the Division of Geriatric Psychiatryand Director of an NIMH-sponsored T32 Research Training Program. Dr. Steffens has established a record of scholarship in the area of geriatric depression, and he serves as Principal Investigator on two large NIMH-funded grants, an R01 focusing on longitudinal geriatric depression outcomes, and on the Recruitment Core of a Conte Neuroscience Center studying cerebrovascular disease in late-life depression. He is the previous recipient of a Clinical Geriatric Mental Health Academic Award (K07). Dr. Steffens has mentored individuals at all levels, including undergraduates, graduate students, medical students, pre- and post-doctoral research fellows, psychiatry residents, geriatric psychiatry fellows, and junior faculty. These experiences makethe candidate well qualified for this K24 Award. Through this Award, the candidate will expand his research by focusing on genes related to folate metabolism in late life depression. Using his funded research as a source for teaching, the candidate will bewell positioned to mentor pre-doctoral and post-doctoral fellows as well asjunior faculty. Under the Award, the candidate will spend at least 50% of his time conducting patient-oriented research and mentoring. Relevance There is a lack of well-trained junior investigators interested in late-life mental health research. With the aging of the population, better understanding of mental illness in older Americans is essential. Support of individuals such as Dr. Steffenswho have an interest and ability to train the next generation of geriatric mental health researchers will help address an important and growing public health need.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24MH070027-09
Application #
8207195
Study Section
Adult Psychopathology and Disorders of Aging Study Section (APDA)
Program Officer
Evans, Jovier D
Project Start
2004-01-15
Project End
2012-06-30
Budget Start
2012-01-01
Budget End
2012-06-30
Support Year
9
Fiscal Year
2012
Total Cost
$52,429
Indirect Cost
$4,575
Name
Duke University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Riddle, Meghan; McQuoid, Douglas R; Potter, Guy G et al. (2015) Disability but not social support predicts cognitive deterioration in late-life depression. Int Psychogeriatr 27:707-14
Hybels, Celia F; Pieper, Carl F; Landerman, Lawrence R et al. (2014) Vascular lesions and functional limitations among older adults: does depression make a difference? Int Psychogeriatr :1-9
Sachs-Ericsson, Natalie; Hames, Jennifer L; Joiner, Thomas E et al. (2014) Differences between suicide attempters and nonattempters in depressed older patients: depression severity, white-matter lesions, and cognitive functioning. Am J Geriatr Psychiatry 22:75-85
Zannas, Anthony S; McQuoid, Douglas R; Payne, Martha E et al. (2014) Association of gene variants of the renin-angiotensin system with accelerated hippocampal volume loss and cognitive decline in old age. Am J Psychiatry 171:1214-21
Qiu, Wendy Wei Qiao; Lai, Angela; Mon, Timothy et al. (2014) Angiotensin converting enzyme inhibitors and Alzheimer disease in the presence of the apolipoprotein E4 allele. Am J Geriatr Psychiatry 22:177-85
Payne, Martha E; McQuoid, Douglas R; Steffens, David C et al. (2014) Elevated brain lesion volumes in older adults who use calcium supplements: a cross-sectional clinical observational study. Br J Nutr 112:220-7
Taylor, Warren D; Kudra, Kamil; Zhao, Zheen et al. (2014) Cingulum bundle white matter lesions influence antidepressant response in late-life depression: a pilot study. J Affect Disord 162:8-11
Jeong, Hyun-Ghang; Han, Changsu; Park, Moon Ho et al. (2014) Influence of the number and severity of somatic symptoms on the severity of depression and suicidality in community-dwelling elders. Asia Pac Psychiatry 6:274-83
Taylor, Warren D; McQuoid, Douglas R; Payne, Martha E et al. (2014) Hippocampus atrophy and the longitudinal course of late-life depression. Am J Geriatr Psychiatry 22:1504-12
Sachs-Ericsson, Natalie; Moxley, Jerad H; Corsentino, Elizabeth et al. (2014) Melancholia in later life: late and early onset differences in presentation, course, and dementia risk. Int J Geriatr Psychiatry 29:943-51

Showing the most recent 10 out of 76 publications