Scott Letendre, M.D. is an Associate Professor of Medicine at UCSD and former K23 Career Development Award recipient. In the past decade, Dr. Letendre has led or collaborated on many publicly and privately funded translational research projects. His influential work has focused on the risk factors and treatment of HIV-associated neurocognitive disorder (HAND) in the US and international settings. During this period, he has also mentored more than 30 trainees in patient-oriented research, including graduate and medical students, post-doctoral researchers, and junior faculty. In the proposed K24 mid-career investigator award, Dr. Letendre will expand his mentoring of junior investigators and will focus his mentoring and his own research on three main objectives. Antiretroviral treatment of the nervous system: Dr. Letendre will mentor trainees on design and performance of HAND clinical trials and CSF pharmacology projects, particularly focusing on longitudinal projects that measure all drugs in an antiretroviral regimen to better understand how drug interactions and time influence virologic and neurocognitive outcomes. Biomarker correlates of disease and treatment: Dr. Letendre will mentor trainees on measurement and analysis of biomarker data with the goal of developing a clinically useful panel for screening, diagnosis, and prognosis of HAND. This work will be supported by new equipment purchased with funds from a recent S10 Shared Instrument Grant. Coinfections in HIV-infected individuals: Dr. Letendre will work with trainees on projects that evaluate the impact on the nervous system of latent or minimally symptomatic infections with pathogens such as Plasmodium, Cytomegalovirus, Toxoplasma, and hepatitis C virus. This work will particularly focus on Dr. Letendre's existing work in international settings. Dr. Letendre will mentor trainees using a multidisciplinary approach that includes regular direct engagement, participation in R25, T32, and K30 programs at UCSD, active participation in existing research projects, support for new research projects, and networking with other investigators. Dr. Letendre will also obtain training in mentoring and analysis of longitudinal data. In summary, this K24 award will secure protected time for Dr. Letendre to mentor trainees in neuroAIDS methods, including the responsible conduct of patient- oriented research. Dr. Letendre will coordinate his efforts with other UCSD resources, including the R25- funded """"""""International Research Fellowship in NeuroAIDS"""""""", the T32-funded """"""""Training in Research on Addictions in Interdisciplinary NeuroAIDS"""""""", and the CTSA-funded """"""""Clinical and Translational Research Institute"""""""".

Public Health Relevance

HIV is one of the most common causes of neurocognitive disorders in adults younger than 49 years old worldwide. This continues to be true even though antiretroviral therapy has largely transformed HIV disease to a chronic illness in many. To help address this problem, the proposed investigator award will support mentoring of scientists in the responsible conduct of patient-oriented neuroAIDS research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
1K24MH097673-01A1
Application #
8466639
Study Section
Behavioral and Social Consequences of HIV/AIDS Study Section (BSCH)
Program Officer
Stoff, David M
Project Start
2012-12-07
Project End
2017-11-30
Budget Start
2012-12-07
Budget End
2013-11-30
Support Year
1
Fiscal Year
2013
Total Cost
$184,743
Indirect Cost
$13,685
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Hoenigl, Martin; Pérez-Santiago, Josué; Nakazawa, Masato et al. (2016) (1→3)-β-d-Glucan: A Biomarker for Microbial Translocation in Individuals with Acute or Early HIV Infection? Front Immunol 7:404
Carvalhal, Adriana; Gill, M John; Letendre, Scott L et al. (2016) Central nervous system penetration effectiveness of antiretroviral drugs and neuropsychological impairment in the Ontario HIV Treatment Network Cohort Study. J Neurovirol 22:349-57
McKenna, Benjamin S; Brown, Gregory G; Archibald, Sarah et al. (2016) Microstructural changes to the brain of mice after methamphetamine exposure as identified with diffusion tensor imaging. Psychiatry Res 249:27-37
Ellis, Ronald; Letendre, Scott L (2016) Update and New Directions in Therapeutics for Neurological Complications of HIV Infections. Neurotherapeutics 13:471-6
de Almeida, Sergio M; Rotta, Indianara; Jiang, Yanxin et al. (2016) Biomarkers of chemotaxis and inflammation in cerebrospinal fluid and serum in individuals with HIV-1 subtype C versus B. J Neurovirol 22:715-724
Bharti, Ajay R; McCutchan, Allen; Deutsch, Reena et al. (2016) Latent Toxoplasma Infection and Higher Toxoplasma gondii Immunoglobulin G Levels Are Associated With Worse Neurocognitive Functioning in HIV-Infected Adults. Clin Infect Dis 63:1655-1660
Cooley, Sarah A; Paul, Robert H; Fennema-Notestine, Christine et al. (2016) Apolipoprotein E ε4 genotype status is not associated with neuroimaging outcomes in a large cohort of HIV+ individuals. J Neurovirol 22:607-614
Kallianpur, Asha R; Wang, Quan; Jia, Peilin et al. (2016) Anemia and Red Blood Cell Indices Predict HIV-Associated Neurocognitive Impairment in the Highly Active Antiretroviral Therapy Era. J Infect Dis 213:1065-73
Wagner, Gabriel A; Chaillon, Antoine; Liu, Siqi et al. (2016) HIV-associated neurocognitive disorder is associated with HIV-1 dual infection. AIDS 30:2591-2597
Fazeli, Pariya L; Moore, David J; Franklin, Donald R et al. (2016) Lower CSF Aβ is Associated with HAND in HIV-Infected Adults with a Family History of Dementia. Curr HIV Res 14:324-30

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