This is a Mid-Career Investigator (K 24) proposal for Ellen Seely, MD. The goal of this proposal is threefold. First, it would increase the depth of Dr. Seely's research by enabling the investigator to receive further advanced training in human genetics. Second, it would give the investigator the supported time to formally train young investigators in patient-oriented research in the field of hormonal control of blood pressure. Third, it would allow the investigator to use her experience as Associate Program Director of the General Clinical Research Center (GCRC) to teach the next generation of patient-oriented researchers about the use of a GCRC for the study of human pathophysiology using varied GCRC-based investigative techniques. Dr. Seely's research topic """"""""Blood Pressure in Postmenopausal Women: a GCRC Study"""""""" serves as fertile ground for a K24. Hypertension affects over 20 million women in the United States and the majority of these women are postmenopausal. Although there is clearly a genetic component to hypertension in both men and women, its incidence increases dramatically in women following menopause superceding that in men and suggests that the hormonal milieu of the premenopausal state may be protective against the manifestation of hypertension. The overall goal of Dr. Seely's research plan is to utilize the GCRC for detailed studies of the pathophysiology of hypertension in postmenopausal women. Dr. Seely plans to determine how polymorphisms of genes of the renin-angiotensin-aldosterone system (RAAS), a major regulator of blood pressure, are influenced by estradiol. An understanding of the interaction of estradiol with specific polymorphisms of the RAAS that lead to blood pressure lowering may enable the development of selective estrogen receptor modulators that have antihypertensive effects. Thus, funding of this proposal will allow Dr. Seely to expand her own research career and simultaneously provide time to expand her mentorship role.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24RR018613-02
Application #
6773302
Study Section
Special Emphasis Panel (ZRG1-CCVS (01))
Program Officer
Wilde, David B
Project Start
2003-07-15
Project End
2008-05-31
Budget Start
2004-06-01
Budget End
2005-05-31
Support Year
2
Fiscal Year
2004
Total Cost
$149,530
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Bellavia, Andrea; Cantonwine, David E; Meeker, John D et al. (2018) Pregnancy urinary bisphenol-A concentrations and glucose levels across BMI categories. Environ Int 113:35-41
Bellavia, Andrea; Hauser, Russ; Seely, Ellen W et al. (2017) Urinary phthalate metabolite concentrations and maternal weight during early pregnancy. Int J Hyg Environ Health 220:1347-1355
James-Todd, Tamarra M; Meeker, John D; Huang, Tianyi et al. (2016) Pregnancy urinary phthalate metabolite concentrations and gestational diabetes risk factors. Environ Int 96:118-126
James-Todd, Tamarra M; Huang, Tianyi; Seely, Ellen W et al. (2016) The association between phthalates and metabolic syndrome: the National Health and Nutrition Examination Survey 2001-2010. Environ Health 15:52
Saxena, A R; Ananth Karumanchi, S; Fan, S-L et al. (2012) Correlation of cystatin-C with glomerular filtration rate by inulin clearance in pregnancy. Hypertens Pregnancy 31:22-30
Ricchiuti, Vincent; Lian, Christine G; Oestreicher, Eveline M et al. (2009) Estradiol increases angiotensin II type 1 receptor in hearts of ovariectomized rats. J Endocrinol 200:75-84
Ahmed, Sofia B; Bentley-Lewis, Rhonda; Hollenberg, Norman K et al. (2009) A comparison of prediction equations for estimating glomerular filtration rate in pregnancy. Hypertens Pregnancy 28:243-55
Mirza, Faryal S; Ong, Paul; Collins, Peter et al. (2008) Effects of estradiol and the angiotensin II receptor blocker irbesartan on vascular function in postmenopausal women. Menopause 15:44-50
Bentley-Lewis, Rhonda; Levkoff, Sue; Stuebe, Alison et al. (2008) Gestational diabetes mellitus: postpartum opportunities for the diagnosis and prevention of type 2 diabetes mellitus. Nat Clin Pract Endocrinol Metab 4:552-8
Szmuilowicz, Emily D; Adler, Gail K; Williams, Jonathan S et al. (2006) Relationship between aldosterone and progesterone in the human menstrual cycle. J Clin Endocrinol Metab 91:3981-7

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