The goal of the South Carolina Clinical and Translational Research Institute (SCTR) is to create a sustainable home at the Medical University of South Carolina (MUSC) to advance clinical and translational research as a distinct discipline and facilitate collaboration across multiple disciplines. The overall approach focuses on: (1) implementing important advances in biomedical science to create opportunities for discovery, (2) removing barriers to facilitate the linkage of knowledge, experience and expertise across disciplinary boundaries, (3) providing training and mentoring experiences to enhance the pipeline for clinical and translational researchers with diverse training and backgrounds, and (4) fostering community engagement with a rapidly growing statewide population that is underserved by many systems to improve their participation and health outcomes. MUSC has long-standing experience leading successful clinical and translational research efforts that span the state. It is the leading state institution in extramurally funded research activities and has a rich research training portfolio. SCTR was established in 2007 with the vision that it would be the """"""""agent of change"""""""" in transforming the research culture at MUSC and statewide via strong relationships with academic and community-based affiliates. Great progress has already been made including the development of an institutional K12 Career Development Program in Clinical and Translational Research, implementation of a pilot project program that funded 29 projects in the first two competitive rounds, and establishment of a robust collaboration with the NIH-funded CTSA at Vanderbilt University for assistance in the SCTR Biomedical Informatics Program. Joining the national CTSA Consortium will accelerate progress by further facilitating (1) development and interoperability of biomedical informatics systems, (2) active exchange of best processes and best practices in evidence-based medicine and community engagement, (3) advancement of clinical and translational science as a discipline and career path;and (4) shared knowledge, experience and collective influence in setting regional and national research agendas and health policy designed to generate the transformative results envisioned by the NIH Roadmap.

Public Health Relevance

SCTR will bring together scientists, clinicians and the lay community to address diseases that commonly impact the citizens of South Carolina. SCTR will coordinate resources and expertise statewide in efficient, innovative approaches to research. Through SCTR, a new generation of researchers will be trained to work across multiple disciplines in collaboration with community members so that scientific discovery is relevant and rapidly translated to front-line treatment settings for maximum impact on healthh outcomes.

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Mentored Career Development Award (KL2)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1)
Program Officer
Purucker, Mary E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Medical University of South Carolina
Schools of Medicine
United States
Zip Code
Benitez, Andreana; Jensen, Jens H; Falangola, Maria Fatima et al. (2018) Modeling white matter tract integrity in aging with diffusional kurtosis imaging. Neurobiol Aging 70:265-275
Nadig, Nandita R; Goodwin, Andrew J; Simpson, Annie N et al. (2017) Patient and Hospital Characteristics Associated with Interhospital Transfer for Adults with Ventilator-Dependent Respiratory Failure. Ann Am Thorac Soc 14:730-736
Scott, Jennifer L; Wirth, Jena R; Eudaly, Jackie et al. (2017) Complete knockout of estrogen receptor alpha is not directly protective in murine lupus. Clin Immunol 183:132-141
Wilmskoetter, Janina; Simpson, Kit N; Bonilha, Heather S (2016) Hospital Readmissions of Stroke Patients with Percutaneous Endoscopic Gastrostomy Feeding Tubes. J Stroke Cerebrovasc Dis 25:2535-42
Wilmskoetter, Janina; Simpson, Annie N; Simpson, Kit N et al. (2016) Practice Patterns of Percutaneous Endoscopic Gastrostomy Tube Placement in Acute Stroke: Are the Guidelines Achievable? J Stroke Cerebrovasc Dis 25:2694-2700
Goodwin, Andrew J; Nadig, Nandita R; McElligott, James T et al. (2016) Where You Live Matters: The Impact of Place of Residence on Severe Sepsis Incidence and Mortality. Chest 150:829-836
Jones Buie, Joy N; Goodwin, Andrew J; Cook, James A et al. (2016) The role of miRNAs in cardiovascular disease risk factors. Atherosclerosis 254:271-281
Vivot, Alexandre; Power, Melinda C; Glymour, M Maria et al. (2016) Jump, Hop, or Skip: Modeling Practice Effects in Studies of Determinants of Cognitive Change in Older Adults. Am J Epidemiol 183:302-14
Majchrzak, Kinga; Nelson, Michelle H; Bailey, Stefanie R et al. (2016) Exploiting IL-17-producing CD4+ and CD8+ T cells to improve cancer immunotherapy in the clinic. Cancer Immunol Immunother 65:247-59
Nelson, Michelle H; Bowers, Jacob S; Bailey, Stefanie R et al. (2016) Toll-like receptor agonist therapy can profoundly augment the antitumor activity of adoptively transferred CD8(+) T cells without host preconditioning. J Immunother Cancer 4:6

Showing the most recent 10 out of 55 publications