Despite great scientific advances over the past decade, the translation of these discoveries to the benefit of patients has been hampered by a number of traditional barriers. The overall goal of the iWioyinit Siimai ImstitiLiiites of ClBrnical &Tiramslatioinial Sciences is to establish a new research paradigm at Mount Sinai, which will create an integrated multidisciplinary environment that will enable translation of cutting-edge research more quickly and easily from """"""""bench-to-bedside-to-implementation"""""""" in the community;train and create an """"""""academic home"""""""" for the clinical and translational investigators of tomorrow;and supply the governance, facilities, resources and opportunities needed to elevate the clinical research enterprise so that clinical investigators can take full advantage of Mount Sinai's Translational Research Institutes and potential collaborators in Mount Sinai Hospital and its affiliates, the School of Medicine and partnering institutions, and other CTSA programs around the country. This transformation will be achieved by fulfilling the following Specific Aims: (1) redesign the institutional research enterprise infrastructure and governance by integrating research functions across administrative, departmental and intellectual boundaries, enhancing and promoting interactions between basic scientists and clinical investigators, and streamlining administrative procedures to facilitate the start-up of clinical trials and the dissemination of results;(2) establish a Translational Discoveries Program to facilitate and expedite clinical research by providing consultation, oversight and facilities for clinical and translational research, engaging the surrounding community and our affiliates to rapidly translate health benefits to the general population, and developing new methodologies to improve clinical trial design and reduce participant burden;(3) train and support the translational investigators of tomorrow by overseeing a multi-disciplinary, doctoral degree-granting program in clinical and translational research for all health care professionals, developing a program to recruit, enhance career development and retain clinical and translational researchers, providing an academic home where new collaborations can be formulated;(4) establish an Experimental Therapeutics&Technologies Program to stimulate the development of new methodologies in clinical and translational research by developing an institution-wide mentored program to identify and develop novel clinical and translational research projects; and (5) establish an institution-wide biomedical information infrastructure that can connect basic researchers, clinical researchers, caregivers and laboratories with an integrated network of information.

Public Health Relevance

The establishment of the ilfloynt Siinao Institutes of Clinical &Tiranslational Sciemces would create an effective, efficient and centralized research administrative structure, foster and reward interdisciplinary collaborations, educate and retain the clinical and translational investigators of the future, enable translation of basic scientific discoveries into clinical practice, and deliver to our diverse community new therapies and a standard of care that would have been unimaginable even five years ago.

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Mentored Career Development Award (KL2)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-CR-1 (02))
Program Officer
Merchant, Carol
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Icahn School of Medicine at Mount Sinai
Schools of Medicine
New York
United States
Zip Code
Kaplan, Benjamin; Caddle-Steele, Carolyn; Chisholm, Gregory et al. (2017) A Culture of Understanding: Reflections and Suggestions from a Genomics Research Community Board. Prog Community Health Partnersh 11:161-165
Srivastava, K D; Song, Y; Yang, N et al. (2017) B-FAHF-2 plus oral immunotherapy (OIT) is safer and more effective than OIT alone in a murine model of concurrent peanut/tree nut allergy. Clin Exp Allergy 47:1038-1049
Schneier, Amanda; Stueck, Ashley E; Petersen, Bruce et al. (2016) An Unusual Cause of Acute Liver Failure: Three Cases of Hemophagocytic Lymphohistiocytosis Presenting at a Transplant Center. Semin Liver Dis 36:99-105
Kirschenbaum, Alexander; Izadmehr, Sudeh; Yao, Shen et al. (2016) Prostatic Acid Phosphatase Alters the RANKL/OPG System and Induces Osteoblastic Prostate Cancer Bone Metastases. Endocrinology 157:4526-4533
Scott, S A; Collet, J-P; Baber, U et al. (2016) Exome sequencing of extreme clopidogrel response phenotypes identifies B4GALT2 as a determinant of on-treatment platelet reactivity. Clin Pharmacol Ther 100:287-94
Sip, Kamila E; Muratore, Alexandra F; Stern, Emily R (2016) Effects of context on risk taking and decision times in obsessive-compulsive disorder. J Psychiatr Res 75:82-90
Amin, Sunil; Boffetta, Paolo; Lucas, Aimee L (2016) The Role of Common Pharmaceutical Agents on the Prevention and Treatment of Pancreatic Cancer. Gut Liver 10:665-71
Magioncalda, Paola; Martino, Matteo; Ely, Benjamin A et al. (2016) Microstructural white-matter abnormalities and their relationship with cognitive dysfunction in obsessive-compulsive disorder. Brain Behav 6:e00442
Amin, S; Mhango, G; Lin, J et al. (2016) Metformin Improves Survival in Patients with Pancreatic Ductal Adenocarcinoma and Pre-Existing Diabetes: A Propensity Score Analysis. Am J Gastroenterol 111:1350-7
Stroustrup, A; Plafkin, C (2016) A pilot prospective study of fetomaternal hemorrhage identified by anemia in asymptomatic neonates. J Perinatol 36:366-9

Showing the most recent 10 out of 41 publications