The University of Chicago (UC) Institute for Translational Medicine (ITM) was created in 2007 to assemble, integrate, and create the intellectual, administrative, and physical resources required to catalyze research and research training in Clinical and Translational Science. Its ultimate goals are to train scientists and health care providers at UC and in our community to determine the molecular, genetic, pathophysiologic and social determinants of disease and disease predisposition in individuals;to test interventions directed toward those mechanisms;and to achieve these goals in a way that is rigorous, efficient, ethical, respectful of, and responsive to our community's needs and values. In its first 4 years, the ITM has capitalized on the outstanding intellectual and physical resources throughout the University and ait ITM affiliate Institutions, Argonne National Laboratory, North Shore University Health System, Illinois Institute of Technology, and Access Community Health Network, and on substantial institutional and CTSA financial investments, to build the infrastructure for a transformative, energized, and self-improving home for clinical and translational research. The impact of the ITM has been greatest in 5 domains: 1) catalyzing the formation of multidisciplinary research teams;2) establishing a systematic, organized clinical and translational research infrastructure;3) engaging our community in research;4) training for careers in clinical and translational team science;and 5) impact on and contributions to the National CTSA Consortium. Building on these, we propose to expand research and training opportunities with five major initiatives: a new TI Research and Technology Cluster;new Cores in Comparative Effectiveness Research and in Social, Environmental, and non-Biological Determinants of Health;a Personalizing Medicine initiative;a new Entrepreneurship Training and Support Program;and a Nurse-rScientist Training Program at new ITM affiliate Rush University. These programs, strengthened by community advice, engagement, partnership and participation, will ensure continued transformation of clinical and translational science at the University of Chicago and affiliates, on the South Side of Chicago, and beyond.

Public Health Relevance

This program leverages the expertise of University of Chicago and affiliated investigators in a broad array of clinical and nonclinical fields to prepare the next generation of clinical and translational researchers to engage with our community partners to identify and prioritize a translational research agenda, and to address and reduce clinical health disparities in diverse adult and pediatric populations in our Community.

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Mentored Career Development Award (KL2)
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Special Emphasis Panel (ZRR1-CR-1 (01))
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Sufian, Meryl
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University of Chicago
Internal Medicine/Medicine
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United States
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Fanning, Jennifer R; Lee, Royce; Coccaro, Emil F (2016) Comorbid intermittent explosive disorder and posttraumatic stress disorder: Clinical correlates and relationship to suicidal behavior. Compr Psychiatry 70:125-33
Goldschmidt, Andrea B; Wall, Melanie; Choo, Tse-Hwei J et al. (2016) Shared risk factors for mood-, eating-, and weight-related health outcomes. Health Psychol 35:245-52
Chor, Julie; Lyman, Phoebe; Tusken, Megan et al. (2016) Women's experiences with doula support during first-trimester surgical abortion: a qualitative study. Contraception 93:244-8
Best, John R; Goldschmidt, Andrea B; Mockus-Valenzuela, Danyte S et al. (2016) Shared weight and dietary changes in parent-child dyads following family-based obesity treatment. Health Psychol 35:92-5
Goldschmidt, Andrea B; Wall, Melanie M; Zhang, Jun et al. (2016) Overeating and binge eating in emerging adulthood: 10-year stability and risk factors. Dev Psychol 52:475-83
Chor, Julie; Tusken, Megan; Lyman, Phoebe et al. (2016) Factors Shaping Women's Pre-abortion Communication with Their Regular Gynecologic Care Providers. Womens Health Issues 26:437-41
Goldschmidt, Andrea B; Wall, Melanie M; Loth, Katie A et al. (2015) Risk Factors for Disordered Eating in Overweight Adolescents and Young Adults. J Pediatr Psychol 40:1048-55
Goldschmidt, Andrea B; Accurso, Erin C; Schreiber-Gregory, Deanna N et al. (2015) Behavioral, emotional, and situational context of purging episodes in anorexia nervosa. Int J Eat Disord 48:341-4
Yu, Dongmei; Mathews, Carol A; Scharf, Jeremiah M et al. (2015) Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD. Am J Psychiatry 172:82-93
Kass, Andrea E; Accurso, Erin C; Goldschmidt, Andrea B et al. (2015) Picking and nibbling in children and adolescents with eating disorders. Int J Eat Disord 48:1102-5

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