To address the CTSA vision to have a sustained and transformative influence on the quality and value of clinical &translational research, leadership from three academic institutions - Emory University, Morehouse School of Medicine, and Georgia Institute of Technology, along with other collaborative organizations formed in 2007, the Atlanta Clinical and Translational Science Institute (ACTSI). The ACTSI has integrated discovery, education, training and community engagement programs and engendered an unprecedented level of transformation in clinical and translational research in our community. The ACTSI has developed an Atlanta """"""""home"""""""" for clinical and translational research through support of: 673 investigators, 520 projects, 93 pilot projects in 96 research areas, over 193 federal (PHS) grants, 134 current or graduated MSCR, KL, or TL scholars, and over 75 additional active trainees. ACTSI support has also contributed to 661 scientific publications, tripled inter-institutional collaborations, and led to important scientific breakthroughs in clinical and translational science. Guided by the mission, """"""""[through ethical community engagement, focused education and training, and innovative support of discovery, the collaborative partners of the ACTSI rapidly and efficiently translate scientific discoveries to impact all populations of the Atlanta community,"""""""" in the next five years, eleven key function programs will be charged with implementing three expanded specific aims.
Aim 1 : Promote discovery through inter-disciplinary collaboration, the development of novel and emerging technologies, drugs, devices, diagnostics and biologies, and the efficient translation of these discoveries to benefit human health.
Aim 2 : Expand and improve outstanding programs to educate and train a growing cadre of ethnically diverse, clinician scientists, and increase the capacity and infrastructure to foster multidisciplinary translational research teams.
Aim 3 : Actively engage the community in research that will engender the public trust in scientific discovery and the translation of new knowledge that ultimately enhances the health of the communities we serve.

Public Health Relevance

Created in response to the NIH CTSA program, the Atlanta CTSI serves as a catalyst and incubator for clinical and translational research across Georgia and with regional and national impact. The goals are to create and accelerate clinical and translational science discovery, build interdisciplinary research capacity, engage communities in health sciences activities, develop new research tools and information technologies, and build the careers of clinical/translational scientists of the future.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Mentored Career Development Award (KL2)
Project #
5KL2TR000455-07
Application #
8499476
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Rosenblum, Daniel
Project Start
2007-09-17
Project End
2017-05-31
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
7
Fiscal Year
2013
Total Cost
$630,513
Indirect Cost
$35,308
Name
Emory University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
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Chinnadurai, Raghavan; Rajan, Devi; Qayed, Muna et al. (2018) Potency Analysis of Mesenchymal Stromal Cells Using a Combinatorial Assay Matrix Approach. Cell Rep 22:2504-2517
Vaccarino, Viola; Sullivan, Samaah; Hammadah, Muhammad et al. (2018) Mental Stress-Induced-Myocardial Ischemia in Young Patients With Recent Myocardial Infarction: Sex Differences and Mechanisms. Circulation 137:794-805
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Pimple, Pratik; Hammadah, Muhammad; Wilmot, Kobina et al. (2018) Chest Pain and Mental Stress-Induced Myocardial Ischemia: Sex Differences. Am J Med 131:540-547.e1
Sullivan, Samaah; Hammadah, Muhammad; Al Mheid, Ibhar et al. (2018) Sex Differences in Hemodynamic and Microvascular Mechanisms of Myocardial Ischemia Induced by Mental Stress. Arterioscler Thromb Vasc Biol 38:473-480
Isakadze, Nino; Soliman, Elsayed Z; Vaccarino, Viola et al. (2018) Association of positive well-being with reduced cardiac repolarization abnormalities in the First National Health and Nutrition Examination Survey. Int J Cardiol 265:246-250
Nickel, Robert Sheppard; Qayed, Muna; Worthington-White, Diana et al. (2018) Infusion hemolysis after pediatric major ABO-mismatched bone marrow transplant: Comparison of two red blood cell depletion techniques. Pediatr Blood Cancer 65:
Qayed, Muna; Wang, Tao; Hemmer, Michael T et al. (2018) Influence of Age on Acute and Chronic GVHD in Children Undergoing HLA-Identical Sibling Bone Marrow Transplantation for Acute Leukemia: Implications for Prophylaxis. Biol Blood Marrow Transplant 24:521-528

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