The hypotheses for this study are based on the results of a substudy of a large, longitudinal epidemiologic investigation (CARDIA), which demonstrated that 24-hr cGMP excretion was higher in African-Americans than whites; higher in men than women; higher in smokers than non- smokers; and higher in persons with a positive family history of hypertension than persons with a negative family history of hypertension. We propose to maintain 20 women (10 pre- and 10 post- menopausal) on two days of low nitrate/nitrite diet and then correlate 24-hr urinary cGMP excretion with resting BP and BP responses to stress. We anticipate that this preliminary study will lead to multiple, larger testings.
Showing the most recent 10 out of 570 publications