This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The purpose of the protocol is to evaluate oral valganciclovir in neonates with symptomatic congenital cytomegalovirus infections involving the central nervous system. Ganciclovir treatment of neonates with symptomatic congenital CMV disease involving the CNS indicates that ganciclovir therapy both improves hearing function (and maintains normal hearing) and prevents hearing deterioration at 6 months.The recent development of a syrup formulation of valganciclovir, the orally bioavailable prodrug of ganciclovir, provides a unique opportunity to seek to build upon the successes of antiviral intervention in this devastating illness.The GCRC is utilized by providing clinical space, nursing staff, funding specialized testing and laboratory support.
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