This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The purpose of this study is to determine the prevalence of atherosclerosis in HIV infected patients and Cofactors of atherosclerosis including traditional HIV-independent risk factors such as smoking, HIV-influenced metabolic risk factors, and novel risk factors relating to inflammation/infection and body composition.This is a cross sectional study of carotid IMT and a longitudinal study of body composition, metabolic markers, and inflammatory markers in a cohort of HIV infected individuals and normal controls. We will also compare IMT, metabolic markers, traditional CDV risk factors such as smoking and blood pressure, and some inflammatory makers to the lager CARDIA cohort and the MESA cohort. We will use these data to determine whether HIV infection is associated with increased atherosclerosis, the potential contributors that lead to atherosclerosis in HIV infection and the progression of fat distribution and metabolic abnormalities in HIV in infected and control subjects.
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