Abstract

The present application proposes to create a university based GCRC at Case Western Reserve University School of Medicine (CWRU). A satellite center at MetroHealth Medical Center is to be added to the long established unit at University Hospitals of Cleveland, and new outpatient activities in Pediatrics are to be supported in the Biomedical Research Building on the CWRU campus. The combined GCRC serves a wide range of research protocols for 58 investigators from 10 departments and 4 institutions. The major areas of research are the following: 1. Pathogenesis of airway responses in normal subjects and those with pulmonary diseases. 2. Carbohydrate and lipid metabolism in pregnancy 4. Sensor and instrument development for infant monitoring 5. Sleep apnea and circadian metabolic function 6. Clinical development of new therapeutics for colon cancer. 7. Traumatic brain injury in children 8. Moderation of central nervous system neurotransmitters in patients with psychiatric illness 9. Functional electronic stimulation of patients with neuro-musculo-skeletal dysfunctions 10. Immune homostasis and clinical treatment trials in AIDS 11. Psychological and development effects of environmental toxins on infants and children 12. Exercise physiology in health and disease in women and men

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000080-35
Application #
2039889
Study Section
General Clinical Research Centers Committee (CLR)
Project Start
1978-12-01
Project End
1998-11-30
Budget Start
1997-01-06
Budget End
1997-11-30
Support Year
35
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Randis, Tara M; Rice, Madeline Murguia; Myatt, Leslie et al. (2018) Incidence of early-onset sepsis in infants born to women with clinical chorioamnionitis. J Perinat Med 46:926-933
Clark, Erin A S; Weiner, Steven J; Rouse, Dwight J et al. (2018) Genetic Variation, Magnesium Sulfate Exposure, and Adverse Neurodevelopmental Outcomes Following Preterm Birth. Am J Perinatol 35:1012-1022
Askie, Lisa M; Darlow, Brian A; Finer, Neil et al. (2018) Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration. JAMA 319:2190-2201
Saade, G R; Thom, E A; Grobman, W A et al. (2018) Cervical funneling or intra-amniotic debris and preterm birth in nulliparous women with midtrimester cervical length less than 30 mm. Ultrasound Obstet Gynecol 52:757-762
Inker, Lesley A; Grams, Morgan E; Levey, Andrew S et al. (2018) Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium. Am J Kidney Dis :
Juraschek, Stephen P; Miller 3rd, Edgar R; Appel, Lawrence J (2018) Orthostatic Hypotension and Symptoms in the AASK Trial. Am J Hypertens 31:665-671
Denson, Lee A; McDonald, Scott A; Das, Abhik et al. (2017) Early Elevation in Interleukin-6 is Associated with Reduced Growth in Extremely Low Birth Weight Infants. Am J Perinatol 34:240-247
DiMarco, Anthony F; Geertman, Robert T; Tabbaa, Kutaiba et al. (2017) Economic Consequences of an Implanted Neuroprosthesis in Subjects with Spinal Cord Injury for Restoration of an Effective Cough. Top Spinal Cord Inj Rehabil 23:271-278
Juraschek, Stephen P; Appel, Lawrence J; Miller 3rd, Edgar R (2017) Metoprolol Increases Uric Acid and Risk of Gout in African Americans With Chronic Kidney Disease Attributed to Hypertension. Am J Hypertens 30:871-875
O'Toole, John F; Bruggeman, Leslie A; Madhavan, Sethu et al. (2017) The Cell Biology of APOL1. Semin Nephrol 37:538-545

Showing the most recent 10 out of 753 publications