This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Preeclampsia remains a major cause of fetal and maternal morbidity and mortality and is one of the most common complications of pregnancy. There is currently neither an effective method of identifying women at risk for developing preeclampsia nor an effective treatment. There are few longitudinal studies measuring potential predictors of preeclampsia. This protocol measures potential biochemical and biophysical markers for prediction of preeclampsia in nulliparous women at low risk for developing preeclampsia. This study is an observational cohort (prediction) study which will recruit four thousand nulliparous pregnant women at low risk for developing preeclampsia who are between 9 and 12 weeks gestational age and whom have been enrolled in the Randomized Clinical Trial of Combined Antioxidant Preeclampsia Prediction Study. Body fluids will be collected and stored for subsequent analyses which can be performed in a nested case control manner.
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