The primary objective of this study is to determine the concentration - response relationship of intravenous BG9719 alone and in association with furosemide in subjects with moderate to severe congestive heart failure and mild to moderate renal failure. Secondary objectives are to determine whether BG9719 alone or in association with furosemide maintain renal function in comparison to furosemide or placebo alone: to determine whether BD9719 alone or in association with furosomide causes less potassium loss than furosemide alone; to determine the difference in sodium excretion concentration-response curves between the association of furosemide and BF9719 relative to BG9719 alone; to assess the evidence of clinical benefit with treatment with BG9719 using global assessment scales, edema score, dyspnea scales, and weight loss; and to determine the tolerability of continuous infusion with BG9719 alone and in association with furosemide.""""""""

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000125-38
Application #
6453126
Study Section
General Clinical Research Centers Committee (CLR)
Project Start
2000-12-01
Project End
2001-11-30
Budget Start
Budget End
Support Year
38
Fiscal Year
2001
Total Cost
Indirect Cost
Name
Yale University
Department
Type
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
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Gidding, Samuel S; Bacha, Fida; Bjornstad, Petter et al. (2018) Cardiac Biomarkers in Youth with Type 2 Diabetes Mellitus: Results from the TODAY Study. J Pediatr 192:86-92.e5
Arslanian, Silva; El Ghormli, Laure; Bacha, Fida et al. (2017) Adiponectin, Insulin Sensitivity, ?-Cell Function, and Racial/Ethnic Disparity in Treatment Failure Rates in TODAY. Diabetes Care 40:85-93
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Krystal, John H (2016) Neuroethology as a translational neuroscience strategy in the era of the NIMH Research Domain Criteria. Psychophysiology 53:364-6

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