This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. PACTG P1025 is a prospective cohort study that provides a framework for collection and evaluation of data and collection of repository specimens from HIV-infected pregnant and postpartum women and their infants. All HIV-infected women who are greater than or equal to 14 weeks gestation with a viable intrauterine pregnancy and intend to continue the pregnancy, or who have recently delivered a liveborn or stillborn infant and are within 14 days after delivery, or are found to be HIV-infected at the time of labor and delivery or within 14 days after delivery, are eligible for enrollment. Women are followed until 12 months postpartum, regardless of the outcome of the pregnancy (e.g. miscarriage, spontaneous abortion). Infants are followed for 6-12 months in P1025 and subsequently rollover into PACTG 219C. Pre-entry assessment may be conducted as early as 10 weeks of gestation.
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