The object of this contract is to provide a statistical and data management facility which will serve the entire AIDS Clinical Trials Group system. This facility will produce efficient and timely protocol development; it will assure the quality of all collected data; it will provide disciplined and uniform study monitoring; and will be responsible for prompt and thorough interim and final statistical analyses of all ACTG studies. In addition, the SDAC will provide leadership in statistical science for the development of broad research strategies for HIV infection; it will participate in the setting of scientific and administrative policy for the ACTG; it will develop novel methods of designing and analyzing AIDS clinical trials responsive to the particular needs of the ACTG; and will conduct cross-study analyses of the ACTG database, such as studies of the natural history of HIV or of prognostic factors for disease progression (such as CD4 levels or viral markers).

Project Start
1989-08-30
Project End
1997-02-28
Budget Start
1997-01-17
Budget End
1997-02-28
Support Year
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Harvard University
Department
Biostatistics & Other Math Sci
Type
Schools of Public Health
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Bebchuk, Judith D; Betensky, Rebecca A (2002) Local likelihood analysis of the latency distribution with interval censored intermediate events. Stat Med 21:3475-91
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Weinberg, A; Betensky, R A; Zhang, L et al. (1998) Effect of shipment, storage, anticoagulant, and cell separation on lymphocyte proliferation assays for human immunodeficiency virus-infected patients. Clin Diagn Lab Immunol 5:804-7
Brambilla, D; Leung, S; Lew, J et al. (1998) Absolute copy number and relative change in determinations of human immunodeficiency virus type 1 RNA in plasma: effect of an external standard on kit comparisons. J Clin Microbiol 36:311-4
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