The goal of this project is to evaluate the chronic toxicity and carcinogenicity of two phthalate plasticizers, dibutyl phthalate (DBP) and di(2-ethylhexyl)phthalate (DEHP), following dietary exposures. 2-Year chronic toxicity and carcinogenicity studies of DBP and DEHP are in the in life phase. Both of these studies include perinatal exposures (exposure during gestation and lactation). Humans are likely to be similarly exposed to these compounds through the environment. Perinatal exposure occurs during critical periods of development and can result in differences in toxicity/carcinogenicity as compared to exposure starting only from adulthood. In the DBP study, rats were exposed perinatally prior to the start of 2-year study, while standard studies are being conducted in mice. DEHP includes two 2-year rat studies, one with perinatal exposure and one without, to evaluate the effect of perinatal exposure. The DBP studies are in the histopathology/report writing phase. The DEHP studies are in the in life phase. Keywords: toxicity, carcinogenicity, diet, perinatal, phthalate, dibutyl phthalate, di(2-ethylhexyl)phthalate.

Agency
National Institute of Health (NIH)
Type
Research and Development Contracts (N01)
Project #
N01ES55541-19-0-2
Application #
8602480
Study Section
Project Start
2005-05-01
Project End
2013-04-30
Budget Start
Budget End
Support Year
Fiscal Year
2013
Total Cost
$693,888
Indirect Cost
Name
Battelle Centers/Pub Health Research & Evaluatn
Department
Type
DUNS #
007901598
City
Columbus
State
OH
Country
United States
Zip Code
43201