The goal of this project is to evaluate the chronic toxicity and carcinogenicity of trans-Resveratrol (RES) in rats and mice exposed by gavage. RES is a non-flavonoid polyphenolic compound found in foods and drinks made from grapes and peanuts. It is currently marketed as a dietary supplement with health benefits including anti-infective, anti-inflammatory and antioxidant properties, lowering total and LDL cholesterol, prevention of wrinkles, increase in longevity, and decrease risk of cardiovascular disease. 2-Year chronic gavage toxicity and carcinogenicity studies of RES are in the in life phase. Keywords: toxicity, carcinogenicity, gavage, trans-resveratrol

Agency
National Institute of Health (NIH)
Type
Research and Development Contracts (N01)
Project #
N01ES55541-19-0-9
Application #
8602487
Study Section
Project Start
2005-05-01
Project End
2013-04-30
Budget Start
Budget End
Support Year
Fiscal Year
2013
Total Cost
$3,844,989
Indirect Cost
Name
Battelle Centers/Pub Health Research & Evaluatn
Department
Type
DUNS #
007901598
City
Columbus
State
OH
Country
United States
Zip Code
43201