Modern research in HIV and alcohol depends heavily on expertise in the areas of study design, statistical nnodeling and inference, and efficient and stable management of data. The inclusion of a Biostatistics Core is motivated by the need to provide access to CARC investigators to the diverse set of tools and expertise required to conduct work in this area. Having a core with faculty and staff from the fields of statistics and data systems management will minimize or eliminate the need for project leaders to seek these resources on their own. The mission ofthe Core is to promote the highest standards for study design, data analysis and data integrity for the individual CARC research projects. The Core will facilitate collaboration between biostatistics faculty and CARC investigators on issues related to design, analysis, and computing. We will work with investigators on standard aspects of design and analysis, and provide access to technical staff needed for formatting variables, constructing databases, implementing data analyses on various software platforms, and archiving project data on secure file servers. We anticipate that several projects will demand development of new methodology, and the faculty configuration of the core is designed to respond to those demands and indeed to generate synergy in methods development. Core operations and resources will be overseen by Dr Joseph Hogan, Professor of Biostatistics at Brown University. Dr Hogan currently co-directs the Outcomes &Biostatistics Core for the Lifespan/Tufts/Brown CFAR, and is an expert on statistical methods for HIV and behavioral science. Core faculty include Dr Hernando Ombao, Associate Professor of Biostatistics at Brown and Tao Liu, Assistant Professor of Biostatistics at Brown. Dr Ombao is an authority on the analysis of brain imaging data, and Dr Liu is experienced in analysis of longitudinal data, causal inference, and statistical methods for HIV. The core will

Public Health Relevance

Modern research in HIV and alcohol relies on innovative study design and statistical modeling. The Biostatistics Core will be staffed by faculty biostatisticians who will ensure that the highest standards of study design and statistical analysis are maintained, and who will develop innovative methods for analysis where needed. In addition, the core will oversee management and archiving of project data.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Research Program Projects (P01)
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Special Emphasis Panel (ZAA1-BB (93))
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Brown University
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Wray, Tyler B; Chan, Philip A; Celio, Mark A et al. (2017) HIV Testing Among Men Who Have Sex with Men in the Northeastern United States. AIDS Behav :
Szymkowicz, Sarah M; Dotson, Vonetta M; McLaren, Molly E et al. (2017) Precuneus abnormalities in middle-aged to older adults with depressive symptoms: An analysis of BDI-II symptom dimensions. Psychiatry Res 268:9-14
Kahler, Christopher W; Liu, Tao; Cioe, Patricia A et al. (2017) Direct and Indirect Effects of Heavy Alcohol Use on Clinical Outcomes in a Longitudinal Study of HIV Patients on ART. AIDS Behav 21:1825-1835
Nunn, Amy; Brinkley-Rubinstein, Lauren; Rose, Jennifer et al. (2017) Latent class analysis of acceptability and willingness to pay for self-HIV testing in a United States urban neighbourhood with high rates of HIV infection. J Int AIDS Soc 20:21290
White, Tara L (2017) Beyond Sensation Seeking: A Conceptual Framework for Individual Differences in Psychostimulant Drug Effects in Healthy Humans. Curr Opin Behav Sci 13:63-70
Thompson, Paul M; Andreassen, Ole A; Arias-Vasquez, Alejandro et al. (2017) ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide. Neuroimage 145:389-408
Sileo, Katelyn M; Kintu, Michael; Kiene, Susan M (2017) The intersection of intimate partner violence and HIV risk among women engaging in transactional sex in Ugandan fishing villages. AIDS Care :1-9
Marshall, Brandon D L; Tate, Janet P; McGinnis, Kathleen A et al. (2017) Long-term alcohol use patterns and HIV disease severity. AIDS 31:1313-1321
Marshall, Brandon David Lewis; Tate, Janet P; Mcginnis, Kathleen A et al. (2017) Long-term alcohol use patterns and HIV disease severity: A joint trajectory analysis. AIDS :
Clark, Uraina S; Sweet, Lawrence H; Morgello, Susan et al. (2017) High early life stress and aberrant amygdala activity: risk factors for elevated neuropsychiatric symptoms in HIV+ adults. Brain Imaging Behav 11:649-665

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