This Shared Resource Core is as part of a POl grant to provide animal testing. The Program Project Director is Dr. R. A. Harris, and the P.I. of this Project is Yuri Blednov and the Co-lnvestigator is Rueben Gonazles. This Animal Core will provide control mice and mice treated with alcohol in a limited access binge consumption model (Drinking in the Dark, DID) for the analysis of miRNA levels (Mayfield Project) as well as mice pre-treated with drugs nominated by the other projects and tested using DID or CPP for gene expression and electrophysiology (Ponomarev/Morikawa Project). This Core will identify alcohol-sensitive therapeutic targets by behavioral testing of new peptides generated in Mihic/Morriset Project, "epigenetic" drugs for Ponomarev/Morikawa project and miRNAs found in the Mayfield project. This behavioral testing will use the DID model of alcohol consumption and Conditioned Place Preference (CPP) in mice and operant self-administration of alcohol in rats.
This core will test the novel targets and ligands developed by the three POl Research Project at the behavioral level and will provide treated animals for study in the other projects. Specifically, discovery of new treatments that will decrease alcohol consumption, self-administration and reward is critical for innovative medication development for alcoholism.
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|Most, Dana; Leiter, Courtney; Blednov, Yuri A et al. (2016) Synaptic microRNAs Coordinately Regulate Synaptic mRNAs: Perturbation by Chronic Alcohol Consumption. Neuropsychopharmacology 41:538-48|
|Marballi, K; Genabai, N K; Blednov, Y A et al. (2016) Alcohol consumption induces global gene expression changes in VTA dopaminergic neurons. Genes Brain Behav 15:318-26|
|Farris, S P; Arasappan, D; Hunicke-Smith, S et al. (2015) Transcriptome organization for chronic alcohol abuse in human brain. Mol Psychiatry 20:1438-47|
|Osterndorff-Kahanek, Elizabeth A; Becker, Howard C; Lopez, Marcelo F et al. (2015) Chronic ethanol exposure produces time- and brain region-dependent changes in gene coexpression networks. PLoS One 10:e0121522|
|Farris, Sean P; Pietrzykowski, Andrzej Z; Miles, Michael F et al. (2015) Applying the new genomics to alcohol dependence. Alcohol 49:825-36|
|Farley, Nicole-Marie M; Mihic, S John (2015) Allosteric modulation of the glycine receptor activated by agonists differing in efficacy. Brain Res 1606:95-101|
|Farris, Sean P; Harris, Robert A; Ponomarev, Igor (2015) Epigenetic modulation of brain gene networks for cocaine and alcohol abuse. Front Neurosci 9:176|
|Most, D; Ferguson, L; Blednov, Y et al. (2015) The synaptoneurosome transcriptome: a model for profiling the emolecular effects of alcohol. Pharmacogenomics J 15:177-88|
|Cornelison, Garrett L; Mihic, S John (2014) Contaminating levels of zinc found in commonly-used labware and buffers affect glycine receptor currents. Brain Res Bull 100:1-5|
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