This Shared Resource Core is as part of a POl grant to provide animal testing. The Program Project Director is Dr. R. A. Harris, and the P.I. of this Project is Yuri Blednov and the Co-lnvestigator is Rueben Gonazles. This Animal Core will provide control mice and mice treated with alcohol in a limited access binge consumption model (Drinking in the Dark, DID) for the analysis of miRNA levels (Mayfield Project) as well as mice pre-treated with drugs nominated by the other projects and tested using DID or CPP for gene expression and electrophysiology (Ponomarev/Morikawa Project). This Core will identify alcohol-sensitive therapeutic targets by behavioral testing of new peptides generated in Mihic/Morriset Project, "epigenetic" drugs for Ponomarev/Morikawa project and miRNAs found in the Mayfield project. This behavioral testing will use the DID model of alcohol consumption and Conditioned Place Preference (CPP) in mice and operant self-administration of alcohol in rats.

Public Health Relevance

This core will test the novel targets and ligands developed by the three POl Research Project at the behavioral level and will provide treated animals for study in the other projects. Specifically, discovery of new treatments that will decrease alcohol consumption, self-administration and reward is critical for innovative medication development for alcoholism.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Program Projects (P01)
Project #
5P01AA020683-02
Application #
8465784
Study Section
Special Emphasis Panel (ZAA1-GG)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
2
Fiscal Year
2013
Total Cost
$104,489
Indirect Cost
$36,727
Name
University of Texas Austin
Department
Type
DUNS #
170230239
City
Austin
State
TX
Country
United States
Zip Code
78712
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Osterndorff-Kahanek, Elizabeth A; Becker, Howard C; Lopez, Marcelo F et al. (2015) Chronic ethanol exposure produces time- and brain region-dependent changes in gene coexpression networks. PLoS One 10:e0121522
Farris, Sean P; Pietrzykowski, Andrzej Z; Miles, Michael F et al. (2015) Applying the new genomics to alcohol dependence. Alcohol 49:825-36
Farley, Nicole-Marie M; Mihic, S John (2015) Allosteric modulation of the glycine receptor activated by agonists differing in efficacy. Brain Res 1606:95-101
Farris, Sean P; Harris, Robert A; Ponomarev, Igor (2015) Epigenetic modulation of brain gene networks for cocaine and alcohol abuse. Front Neurosci 9:176
Most, D; Ferguson, L; Blednov, Y et al. (2015) The synaptoneurosome transcriptome: a model for profiling the emolecular effects of alcohol. Pharmacogenomics J 15:177-88
Cornelison, Garrett L; Mihic, S John (2014) Contaminating levels of zinc found in commonly-used labware and buffers affect glycine receptor currents. Brain Res Bull 100:1-5

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