Core B: Clinical This Core evaluates and follows all participants entered into the studies of the program project. It uses established clinical and psychometric protocols (including Uniform Data Set assessments) at entry and annually thereafter to obtain clinical, neurological, and behavioral data to carefully characterize each participant, including dementia diagnosis and staging. Clinical Core data are used by all Cores and Projects to explore the correlates of very mild dementia of the Alzheimer type (DAT) in comparison with healthy brain aging. Core B: Clinical recruits and maintains an adequate sample size to supply needed participants for the projects. There is an increased need for nondemented participants as the program project explores AD changes in the brain prior to the occurrence of dementia (preclinical AD). The Core will refer participants to Core E: Imaging to obtain the Common Anatomic Protocol, assess participants in Project 1 ("Preclinical AD predicts poststroke dementia") 1-year poststroke and annually thereafter, obtain blood from all participants for analysis in Project 2 ("Antecedent biomarkers of AD in CSF and plasma") and Project 4 ("Sequence variation in genes for biomarker proteins and age at onset of AD"), and refer participants to Project 2 for CSF collection and to Project 3 ("Markers for DAT: Control, variability, and personality") for study participation. Through its successful voluntary autopsy program the Core provides Core D: Neuropathology with autopsy material for neuropathologic diagnosis. Core B works closely with Core C: Biostatistics to ensure appropriate data management. The Core supports Core A: Administration in promoting scientific interactions among all investigators to accomplish the aims of the program project as a whole.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG003991-30
Application #
8425010
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
Project End
2014-12-31
Budget Start
2013-01-01
Budget End
2013-12-31
Support Year
30
Fiscal Year
2013
Total Cost
$520,338
Indirect Cost
$178,013
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Su, Yi; Blazey, Tyler M; Snyder, Abraham Z et al. (2015) Partial volume correction in quantitative amyloid imaging. Neuroimage 107:55-64
Shim, Yong Soo; Yang, Dong-Won; Roe, Catherine M et al. (2015) Pathological correlates of white matter hyperintensities on magnetic resonance imaging. Dement Geriatr Cogn Disord 39:92-104
Wang, Li-San; Naj, Adam C; Graham, Robert R et al. (2015) Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol 72:209-16
Ghoshal, Nupur; Perry, Arie; McKeel, Daniel et al. (2015) Variably Protease-sensitive Prionopathy in an Apparent Cognitively Normal 93-Year-Old. Alzheimer Dis Assoc Disord 29:173-6
Hurth, Kyle; Tarawneh, Rawan; Ghoshal, Nupur et al. (2015) Whipple's disease masquerades as dementia with Lewy bodies. Alzheimer Dis Assoc Disord 29:85-9
Aschenbrenner, Andrew J; Balota, David A; Tse, Chi-Shing et al. (2015) Alzheimer disease biomarkers, attentional control, and semantic memory retrieval: Synergistic and mediational effects of biomarkers on a sensitive cognitive measure in non-demented older adults. Neuropsychology 29:368-81
Lim, Miranda M; Gerstner, Jason R; Holtzman, David M (2014) The sleep-wake cycle and Alzheimer's disease: what do we know? Neurodegener Dis Manag 4:351-62
Pizzie, Rachel; Hindman, Halley; Roe, Catherine M et al. (2014) Physical activity and cognitive trajectories in cognitively normal adults: the adult children study. Alzheimer Dis Assoc Disord 28:50-7
Fagan, Anne M; Xiong, Chengjie; Jasielec, Mateusz S et al. (2014) Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease. Sci Transl Med 6:226ra30
Harari, Oscar; Cruchaga, Carlos; Kauwe, John S K et al. (2014) Phosphorylated tau-A?42 ratio as a continuous trait for biomarker discovery for early-stage Alzheimer's disease in multiplex immunoassay panels of cerebrospinal fluid. Biol Psychiatry 75:723-31

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