The central theme of this program is to study aging of the human knee joint and its relationship to osteoarthritis (OA). The Administrative Core will focus efforts of the cores and projects on this theme, advance hypotheses and research directions and ascertain scientific progress. The core will provide administrative support for the most efficient utilization of resources. The core will maintain access to different sources of knee joints and cartilage and monitor sample processing by the cores and analysis by the projects. Core A also serves as the central unit for data management and maintains the database for all knee specimens that are studied in the program.
The Specific Aims of the Administrative Core are:
Aim 1. Monitor scientific progress in the individual projects.
Aim 2. Promote interactions among the investigators in the program.
Aim 3. Support young scientists and development of new projects.
Aim 4. Provide access to knees and cartilage samples.
Aim 5. Maintain central database.
Aim 6. Perform statistical analysis.
Aim 7. Coordinate all fiscal activities of the program.
Aim 8. Ascertain responsible conduct of research.
Aim 9. Enforce safety measures for work with hazardous materials.
Aim 1 0. Distribute tissues and tissue extracts to outside investigators.
Osteoarthritis represents the most prevalent joint disease for which disease-modifying therapies are not available. Aging is the major risk factor for the development of OA, and this project is focused on the discovery of biomarkers and therapeutic targets. A multidisciplinary appoach is used to study aging and OA related changes in the human knee. This core serves the function to thematically focus and direct the program.
|Terkeltaub, Robert (2014) Apolipoprotein a-I at the interface of vascular inflammation and arthritis. Arterioscler Thromb Vasc Biol 34:474-6|
|Zhao, Xianling; Petursson, Freyr; Viollet, Benoit et al. (2014) Peroxisome proliferator-activated receptor ? coactivator 1? and FoxO3A mediate chondroprotection by AMP-activated protein kinase. Arthritis Rheumatol 66:3073-82|
|Alvarez-Garcia, Oscar; Rogers, Nicole H; Smith, Roy G et al. (2014) Palmitate has proapoptotic and proinflammatory effects on articular cartilage and synergizes with interleukin-1. Arthritis Rheumatol 66:1779-88|
|Kato, Tomohiro; Miyaki, Shigeru; Ishitobi, Hiroyuki et al. (2014) Exosomes from IL-1? stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes. Arthritis Res Ther 16:R163|
|Grogan, Shawn P; Chen, Xian; Sovani, Sujata et al. (2014) Influence of cartilage extracellular matrix molecules on cell phenotype and neocartilage formation. Tissue Eng Part A 20:264-74|
|Mologne, Timothy S; Cory, Esther; Hansen, Bradley C et al. (2014) Osteochondral allograft transplant to the medial femoral condyle using a medial or lateral femoral condyle allograft: is there a difference in graft sources? Am J Sports Med 42:2205-13|
|Onizuka, Naoko; Ito, Yoshiaki; Inagawa, Masayo et al. (2014) The Mohawk homeobox transcription factor regulates the differentiation of tendons and volar plates. J Orthop Sci 19:172-80|
|Novitskaya, Ekaterina; Zin, Carolyn; Chang, Neil et al. (2014) Creep of trabecular bone from the human proximal tibia. Mater Sci Eng C Mater Biol Appl 40:219-27|
|Shapiro, Irving M; Layfield, Robert; Lotz, Martin et al. (2014) Boning up on autophagy: the role of autophagy in skeletal biology. Autophagy 10:7-19|
|Olee, Tsaiwei; Grogan, Shawn P; Lotz, Martin K et al. (2014) Repair of cartilage defects in arthritic tissue with differentiated human embryonic stem cells. Tissue Eng Part A 20:683-92|
Showing the most recent 10 out of 238 publications