Why is it that low levels of education are associated with worse adult health and higher mortality? Despite decades of research, we know surprisingly little about the mechanisms through which education influences mortality and health. Though a dense literature documents the mediating role of factors such as income, risk behaviors, and environmental exposures, there are only a handful of investigations that explore early environments (genetic, material, familial, social and emotional). In this project, we focus on very early conditions (some inherited) that drive the child's physical and mental growth and development, including episodes of ill health, but more broadly exposure to a range of stressors linked to deprivation, family characteristics and parental behavior and expectations. We conjecture that these factors contribute to the formation of cognitive and non cognitive resources that influence educational attainment and, ultimately, adult physical and mental health. As an important innovation, part of our investigation will focus on specific genetic traits recently suspected to be involved in the modification of the effects of educational attainment (or of some of the factors responsible for it) on mental health.
The aims of this project will include 1) developing a methodology to estimate the importance of cognitive and non-cognitive factors as mechanisms that mediate the relationship between education and health by decomposing the effects of education on health and mortality into a component due to cognitive and non-cognitive traits and another due to standard factors (i.e. material resources, health behaviors);2) testing the hypothesis that educational attainment has become a stronger determinant of health and mortality across time in part because of the salience of early conditions as determinants of both educational attainment and health status and mortality and 3) evaluating the role of genetic endowments in moderating the relationship between education and mental health outcomes.

Public Health Relevance

The proposed research is part of an effort to understand the relationship between education and health across the life course and across cohorts. We explore the role of genetic endowments, early life adverse experiences, cognitive and non-cognitive resources, as well as traditional mechanisms such as material resources.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG009975-17
Application #
8707298
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
17
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02115
Lin, Chen; Chang, Yi-Chung; Cheng, Ya-Chen et al. (2016) Probing the Fractal Pattern of Heartbeats in Drosophila Pupae by Visible Optical Recording System. Sci Rep 6:31950
Yeh, Chien-Hung; Lo, Men-Tzung; Hu, Kun (2016) Spurious cross-frequency amplitude-amplitude coupling in nonstationary, nonlinear signals. Physica A 454:143-150
Vetrivelan, Ramalingam; Kong, Dong; Ferrari, Loris L et al. (2016) Melanin-concentrating hormone neurons specifically promote rapid eye movement sleep in mice. Neuroscience 336:102-113
Markt, Sarah C; Flynn-Evans, Erin E; Valdimarsdottir, Unnur A et al. (2016) Sleep Duration and Disruption and Prostate Cancer Risk: a 23-Year Prospective Study. Cancer Epidemiol Biomarkers Prev 25:302-8
Morris, Christopher J; Purvis, Taylor E; Hu, Kun et al. (2016) Circadian misalignment increases cardiovascular disease risk factors in humans. Proc Natl Acad Sci U S A 113:E1402-11
Klerman, Elizabeth B; Beckett, Scott A; Landrigan, Christopher P (2016) Applying mathematical models to predict resident physician performance and alertness on traditional and novel work schedules. BMC Med Educ 16:239
Lo, Men-Tzung; Chiang, Wei-Yin; Hsieh, Wan-Hsin et al. (2016) Interactive Effects of Dorsomedial Hypothalamic Nucleus and Time-Restricted Feeding on Fractal Motor Activity Regulation. Front Physiol 7:174
Shaw, Natalie D; McHill, Andrew W; Schiavon, Michele et al. (2016) Effect of Slow Wave Sleep Disruption on Metabolic Parameters in Adolescents. Sleep 39:1591-9
Duffy, Jeanne F; Scheuermaier, Karine; Loughlin, Kevin R (2016) Age-Related Sleep Disruption and Reduction in the Circadian Rhythm of Urine Output: Contribution to Nocturia? Curr Aging Sci 9:34-43
Bermudez, Eduardo B; Klerman, Elizabeth B; Czeisler, Charles A et al. (2016) Prediction of Vigilant Attention and Cognitive Performance Using Self-Reported Alertness, Circadian Phase, Hours since Awakening, and Accumulated Sleep Loss. PLoS One 11:e0151770

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