The overarching goal of this competitive renewal application is to examine the pleiotropic effects of arteriosclerosis (AS), on brain structure and function, either alone or in combination with Alzheimer disease (AD). We propose a prospective, longitudinal study of a convenience sample (231 current + 276 new = 507 subjects), selected using the Framingham cardiovascular risk profile (FCRP) to ensure representation of subjects ranging from little to severe arteriosclerosis (AS). The PPG includes 4 Cores (Administrative, Clinical, Imaging, and Pathology) and 4 Projects. Project 1 (Reed &Jagust) will use amyloid imaging (Pittsburgh Imaging B [PIB] compound) to identify in vivo a cohort of subjects representing the full spectrum of AS, with minimal AD pathology. Project 2 (Weiner, DeCarli, and Singh) will determine the extent to which arteriosclerosis (AS) is associated with changes of brain perfusion and volume and integrity of gray matter (GM) and white matter (WM) and the extent to which these associations relate to AD- vs. CVD-pathology. .Project 6 (Zarow &Vinters) seeks to improve the clinical diagnosis of hippocampal sclerosis and to clarify its pathogenesis. Project 7 (Chui &Mungas) will test the overarching hypothesis using data obtained in the Clinical, Imaging, and Pathology Cores.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG012435-16
Application #
7848856
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4 (J2))
Program Officer
Buckholtz, Neil
Project Start
1997-09-15
Project End
2013-05-31
Budget Start
2010-06-01
Budget End
2011-05-31
Support Year
16
Fiscal Year
2010
Total Cost
$1,867,173
Indirect Cost
Name
University of Southern California
Department
Neurology
Type
Schools of Medicine
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
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Lao, Yi; Nguyen, Binh; Tsao, Sinchai et al. (2017) A T1 and DTI fused 3D corpus callosum analysis in MCI subjects with high and low cardiovascular risk profile. Neuroimage Clin 14:298-307
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Bron, Esther E; Smits, Marion; van der Flier, Wiesje M et al. (2015) Standardized evaluation of algorithms for computer-aided diagnosis of dementia based on structural MRI: the CADDementia challenge. Neuroimage 111:562-79
Vinters, Harry V (2015) Emerging concepts in Alzheimer's disease. Annu Rev Pathol 10:291-319
Hinman, Jason D; Lee, Monica D; Tung, Spencer et al. (2015) Molecular disorganization of axons adjacent to human lacunar infarcts. Brain 138:736-45
Yokoyama, Jennifer S; Lee, Allen K L; Takada, Leonel T et al. (2015) Apolipoprotein ?4 is associated with lower brain volume in cognitively normal Chinese but not white older adults. PLoS One 10:e0118338
Frazier, Darvis T; Seider, Talia; Bettcher, Brianne M et al. (2014) The role of carotid intima-media thickness in predicting longitudinal cognitive function in an older adult cohort. Cerebrovasc Dis 38:441-7

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