The goal of the Administrative and Data Management Core (Core B) of this Program Project Grant (PPG) is to maximize the productivity of all participants by the coordination and integration of scientific, fiscal and administrative activities, and provide a coordinated mechanism for data analysis and management. Core B is directed by the overall PI of the PPG, will continue to provide support to all four Projects in the PPG, as well as Core A, The Nonhuman Primate Core, at the California National Primate Research Center (CNPRC). The specific responsibilities of Core B are as follows: 1) To provide leadership and an administrative framework to facilitate interactions and communications among all the participating Project and Core Leaders (PLs) and across the multiple sites by creating a centralized mechanism for the coordination and management of research activities. 2) To centralize the administration of fiscal, clerical and personnel matters, and provide an administrative liaison between the Grants and Contracts Office of the Mount Sinai School of Medicine and other sites where research is conducted. 3. To organize all travel for perfusions of non-human primates at the CNPRC and assure that tissues are properly distributed. To assist Dr. Gore as needed in organizing and coordinating all distribution of rat tissues, which originate from Project 2 at The University of Texas at Austin. 4) To provide assistance with statistical analysis to all individual Projects, and in particular, provide analysis for comparisons of findings across Projects. Also, Core B will provide a consolidated mechanism for data organization and storage. 5) To ensure the smooth function and integration of PPG components by organizing frequent informal meetings, video conferences, and teleconferences with other PLs as well as formal meetings with the External Advisory Committee. 6) To facilitate the use of resources generated through this program by other investigators.

Public Health Relevance

This core fosters the integration and collaboration required for the Program Project participants to reach their goal: to understand the aging brain and female reproductive senescence and develop hormone treatments applicable to women that will maximize neurological health.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program Projects (P01)
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Special Emphasis Panel (ZAG1-ZIJ-9)
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Icahn School of Medicine at Mount Sinai
New York
United States
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Marques-Lopes, Jose; Van Kempen, Tracey; Waters, Elizabeth M et al. (2014) Slow-pressor angiotensin II hypertension and concomitant dendritic NMDA receptor trafficking in estrogen receptor ?-containing neurons of the mouse hypothalamic paraventricular nucleus are sex and age dependent. J Comp Neurol 522:3075-90
McEwen, B S (2014) Sex, stress and the brain: interactive actions of hormones on the developing and adult brain. Climacteric 17 Suppl 2:18-25
Almey, Anne; Cannell, Elizabeth; Bertram, Kyla et al. (2014) Medial prefrontal cortical estradiol rapidly alters memory system bias in female rats: ultrastructural analysis reveals membrane-associated estrogen receptors as potential mediators. Endocrinology 155:4422-32
Picard, Martin; McEwen, Bruce S (2014) Mitochondria impact brain function and cognition. Proc Natl Acad Sci U S A 111:7-8
Morrison, John H; Baxter, Mark G (2014) Synaptic health. JAMA Psychiatry 71:835-7
Wu, Melody V; Shamy, Jul Lea; Bedi, Gillinder et al. (2014) Impact of social status and antidepressant treatment on neurogenesis in the baboon hippocampus. Neuropsychopharmacology 39:1861-71
Kermath, Bailey A; Riha, Penny D; Woller, Michael J et al. (2014) Hypothalamic molecular changes underlying natural reproductive senescence in the female rat. Endocrinology 155:3597-609
Hara, Yuko; Yuk, Frank; Puri, Rishi et al. (2014) Presynaptic mitochondrial morphology in monkey prefrontal cortex correlates with working memory and is improved with estrogen treatment. Proc Natl Acad Sci U S A 111:486-91
Young, M E; Ohm, D T; Dumitriu, D et al. (2014) Differential effects of aging on dendritic spines in visual cortex and prefrontal cortex of the rhesus monkey. Neuroscience 274:33-43
Naugle, Michelle M; Gore, Andrea C (2014) GnRH neurons of young and aged female rhesus monkeys co-express GPER but are unaffected by long-term hormone replacement. Neuroendocrinology 100:334-46

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