PROJECT SUMIVIARY: Core A is the Administrative Core of this Program Project Grant (PPG), which is designed to elucidate mechanisms of brain degeneration in hereditary and sporadic frontotemporal dementia (FTD) or Frontotemporal degeneration (FTLD). As such, Core A exercises fiscal and administrative oversight ofthe PPG, facilitates interactions among PPG investigators to accomplish the research program outlined here, coordinates and integrates activities of the Projects/Cores, and provides mechanisms to advise the Principal Investigator (PI) and Core/Project Leaders of this PPG on their progress towards accomplishing its goals. Budgetary and administrative matters will be handled by Core A personnel, while oversight ofthe progress of each Core/Project and the overall PPG will be accomplished by several complementary mechanisms: 1) Bi-weekly meetings of PPG investigators to review ongoing collaborations;2) Monthly meetings of Core/Project investigators, students, fellows and technicians to review progress, accomplishments and problems that arise;3) Organize visits by external scientific advisory committee members;4) Participation by PPG investigators in annual 1-2 day scientific retreats held by the Centerfor Neurodegenerative Disease Research, Institute on Aging and the Institute of Neurological Sciences at Penn, which include presentations by outside speakers and poster sessions wherein students, fellows and faculty from all fields of clinical/basic neuroscience and aging research present their latest findings in an informal setting;5) Participation by PPG investigators in annual meetings of national scientific organizations to present research from this PPG and keep abreast of related scientific advances on the national and international level. Hence, Core A provides a flexible but cleariy delineated administrative structure to foster and facilitate efforts by PPG . investigators to elucidate mechanisms of brain degeneration in hereditary and sporadic FTD/FTLD.
Administrative Core A is highly relevant to this Program Project Grant (PPG) on frontotemporal lobar degeneration (FTLD) because it exercises fiscal and administrative oversight over this PPG , facilitates interactions among PPG investigators to accomplish the research program on FTLD outlined here, coordinates and integrates activities of the Projects/Cores, and provides mechanisms to advise the Principal Investigator and Core/Project Leaders of this PPG on their progress towards accomplishing its goals.
|Spinelli, Edoardo G; Mandelli, Maria Luisa; Miller, Zachary A et al. (2017) Typical and atypical pathology in primary progressive aphasia variants. Ann Neurol 81:430-443|
|Berson, Amit; Sartoris, Ashley; Nativio, Raffaella et al. (2017) TDP-43 Promotes Neurodegeneration by Impairing Chromatin Remodeling. Curr Biol 27:3579-3590.e6|
|Nevler, Naomi; Ash, Sharon; Jester, Charles et al. (2017) Automatic measurement of prosody in behavioral variant FTD. Neurology 89:650-656|
|Cousins, Katheryn A Q; Ash, Sharon; Irwin, David J et al. (2017) Dissociable substrates underlie the production of abstract and concrete nouns. Brain Lang 165:45-54|
|Zylstra, Bradley; Netscher, George; Jacquemot, Julien et al. (2017) Extended, continuous measures of functional status in community dwelling persons with Alzheimer's and related dementia: Infrastructure, performance, tradeoffs, preliminary data, and promise. J Neurosci Methods :|
|Phillips, Jeffrey S; Da Re, Fulvio; Dratch, Laynie et al. (2017) Neocortical origin and progression of gray matter atrophy in nonamnestic Alzheimer's disease. Neurobiol Aging 63:75-87|
|Dong, Aoyan; Toledo, Jon B; Honnorat, Nicolas et al. (2017) Heterogeneity of neuroanatomical patterns in prodromal Alzheimer's disease: links to cognition, progression and biomarkers. Brain 140:735-747|
|Lee, Edward B; Porta, Sílvia; Michael Baer, G et al. (2017) Expansion of the classification of FTLD-TDP: distinct pathology associated with rapidly progressive frontotemporal degeneration. Acta Neuropathol 134:65-78|
|Ballatore, Carlo; Brunden, Kurt R; Trojanowski, John Q et al. (2017) Non-Naturally Occurring Small Molecule Microtubule-Stabilizing Agents: A Potential Tactic for CNS-Directed Therapies. ACS Chem Neurosci 8:5-7|
|Kim, Benjamin J; Irwin, David J; Song, Delu et al. (2017) Optical coherence tomography identifies outer retina thinning in frontotemporal degeneration. Neurology 89:1604-1611|
Showing the most recent 10 out of 549 publications