Core C will serve as the Mitochondrial Function Core of the Program Project. Dr. Bai will serve as the Leaderof Core C. Core C will be responsible for the following functions in the Program Project:1. To provide tools and analytic approachesto study mitochondrial biogenesis including mitochondria! DMAcontent, mitochondrial RNA level, mitochondrial protein synthesis and respiratory complex assembly, andhelp to quantitatively detect the mitochondrial DMAmutations for all of the principal investigators of theprogram project who require such analysesfor the proposed studies.2. To provide tools and approachesto analyze mitochondrialfunction including measuring total respiration,complex-dependent respiration, growth capacitywhile cells predominantly rely on mitochondria for ATPproduction and ATP level, and to perform respiratory enzymesassays and create mitochondrial DNA-lesscell models for the principal investigators of the program projectwho require such analysesfor the proposedstudies.3. To provide consultation regarding the availability of existing and new approachesto study mitochondrialbiogenesis and function to the participants of this program project and to insure the quality of relevantresearch conducted by the Projects and Cores.
Showing the most recent 10 out of 120 publications
