Primary progressive aphasia (PPA) is one of the clinical presentations of the frontotemporal dementia- spectrum disorders. It occurs when neurodegeneration selectively targets the language networks of the brain. Discoveries from previous cycles of this PPG were fundamental in characterizing PPA and its main clinic- anatomical presentations: the nonfluent/agrammatic (nfvPPA), semantic (svPPA) and logopenic (lvPPA) variants. These three syndromes are associated with specific patterns of language and anatomical damage, and are each thought to have different probable underlying molecular causes. Despite these significant advances in PPA characterization, many questions regarding clinical heterogeneity, prognosis and biological basis remain unanswered. In this project, we will take advantage of the wealth of multidisciplinary expertise and data available through this PPG to investigate differential diagnosis, clinical and neuroimaging progression and in-vivo pathological prediction in PPA. We propose a five-year cross-sectional and longitudinal study of the cognitive, anatomical and biological features of more than 100 newly recruited individuals with PPA. We will use the most modern techniques, from computerized, tablet-based cognitive tests to molecular neuroimaging and gene expression, to develop principles and diagnostic concepts that can also be applied in less specialized settings. In particular, in Aim 1 we will use validated and tablet-based tests of visuo-spatial, executive and socio-emotional functions to study non-language features in the PPA variants. We hypothesize that specific patterns of cognitive dysfunction will be found in each PPA variant at presentation and at 1-year follow-up, depending on the anatomical network involved.
In Aim 2, we will use the human healthy connectome architecture to predict longitudinal neuroimaging changes in PPA. Based on the transynaptic-spread theory of neurodegeneration, we hypothesize that regions strongly connected to syndrome-specific epicenters will show atrophy and molecular PET changes at one-year follow-up. Finally, in Aim 3, we will combine clinical, neuroimaging, genetic and pathological data in the largest and most comprehensive PPA dataset ever examined, in a multivariate analyze that will determine whether molecular diagnosis can be predicted in-vivo. This project will provide crucial data for the diagnosis of neurodegenerative diseases in their early stages, when treatment can be most effective.
The research focuses on Primary Progressive Aphasia (PPA), a fatal neurodegenerative disorder that manifests with speech and language symptoms. In this project, we will combine cognitive, neuroimaging and biological data from a large PPA cohort with the goal of improving differential diagnosis, prognosis and ultimately treatment of this devastating disorder.
| Miller, Zachary A; Rosenberg, Lynne; Santos-Santos, Miguel A et al. (2018) Prevalence of Mathematical and Visuospatial Learning Disabilities in Patients With Posterior Cortical Atrophy. JAMA Neurol 75:728-737 |
| Rojas, Julio C; Stephens, Melanie L; Rabinovici, Gil D et al. (2018) Multiproteinopathy, neurodegeneration and old age: a case study. Neurocase 24:1-6 |
| Dijkstra, Anke A; Lin, Li-Chun; Nana, Alissa L et al. (2018) Von Economo Neurons and Fork Cells: A Neurochemical Signature Linked to Monoaminergic Function. Cereb Cortex 28:131-144 |
| Mok, Sue-Ann; Condello, Carlo; Freilich, Rebecca et al. (2018) Mapping interactions with the chaperone network reveals factors that protect against tau aggregation. Nat Struct Mol Biol 25:384-393 |
| Erkkinen, Michael G; Zúñiga, Raquel Gutiérrez; Pardo, Cristóbal Carnero et al. (2018) Artistic Renaissance in Frontotemporal Dementia. JAMA 319:1304-1306 |
| Schneider, Raphael; McKeever, Paul; Kim, TaeHyung et al. (2018) Downregulation of exosomal miR-204-5p and miR-632 as a biomarker for FTD: a GENFI study. J Neurol Neurosurg Psychiatry 89:851-858 |
| Ljubenkov, Peter A; Staffaroni, Adam M; Rojas, Julio C et al. (2018) Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory. Ann Clin Transl Neurol 5:1250-1263 |
| La Joie, Renaud; Bejanin, Alexandre; Fagan, Anne M et al. (2018) Associations between [18F]AV1451 tau PET and CSF measures of tau pathology in a clinical sample. Neurology 90:e282-e290 |
| Kim, Eun-Joo; Brown, Jesse A; Deng, Jersey et al. (2018) Mixed TDP-43 proteinopathy and tauopathy in frontotemporal lobar degeneration: nine case series. J Neurol 265:2960-2971 |
| Henry, Maya L; Hubbard, H Isabel; Grasso, Stephanie M et al. (2018) Retraining speech production and fluency in non-fluent/agrammatic primary progressive aphasia. Brain 141:1799-1814 |
Showing the most recent 10 out of 607 publications
