The purpose of Project 4 is to collect comprehensive biological assessments, paralleling those obtained on the existing MIDUS II sample, on a new refresher sample of 800 individuals (aged 25-54) recruited from the Project 1 refresher samples. Approximately 650 respondents will be from the national probability sample (N = 2,100), while 150 will be from the new African American sample in Milwaukee, Wl (N=500). These additions will increase the size of the existing biomarker sample (N = 1,255) by about 65% (62% for RDD, 75% for Milwaukee). Participants will travel to one of three clinical research centers (University of California, Los Angeles;University of Wisconsin, Madison;Georgetown University, Washington, DC) for an overnight stay. Data to will be collected across four biological systems: neuroendocrine, inflammatory, cardiovascular, and musculoskeletal. A laboratory study will include measures of blood pressure, heart-rate variability, respiratory rate, and salivary cortisol before, during and after various challenges (cognitive and orthostatic). In response to prior concerns about innovation, we have added an expanded cytokine panel, metabolic profiling, and insulin-like growth factor (IGF-1), all of which will be assessed in the new refresher biomarker sample as well as the MIDUS 11 biomarker sample (using stored specimens). Key rationales for augmenting the biomarker sample are to: (a) establish baseline biomarkers for young adults aged 25-34 who are missing from the current sample because biomarkers were added at the 2 wave of MIDUS;(b) afford tests of period effects, linked to the economic recession, in biomarker levels (e.g., cortisol, catecholamines, inflammation, blood pressure, waist-hip ratio;glucose and lipid regulation);and (c) expand the size of the biomarker sample (Refresher + MIDUS II) needed for cross-project analyses investigating the interplay between sociodemographic and psychosocial factors in predicting biomarker levels. Many hypotheses will be pursued, but overarching predictions are that major economic upheaval can be consequential for biological regulation, with such effects likely moderated by sociodemographic status variables (e.g., income, education) as well as by psychosocial factors (e.g., quality of social relationships, well-being). Because this P01 will also include longitudinal follow-up for survey (Project 1) and cognitive (Project 3) assessments of the existing sample, a further aim will be to begin analyses that investigate biological systems (assessed at MIDUS II) as mediators of relationships between prior psychosocial factors (MIDUS I &II) and unfolding profiles of morbidity and mortality (MIDUS III).

Public Health Relevance

The societal significance of the proposed research is that MIDUS will advance knowledge of how sociodemographic and psychosocial factors in early and middle adulthood contribute to, or protect against, risk in multiple biological systems that influence later life morbidity and mortality. Because many psychosocial factors are modifiable, they serve as important targets for prevention and positive health promotion in the U.S. population.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program Projects (P01)
Project #
Application #
Study Section
National Institute on Aging Initial Review Group (NIA)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Wisconsin Madison
United States
Zip Code
Cornman, Jennifer C; Glei, Dana A; Goldman, Noreen et al. (2015) Socioeconomic status and biological markers of health: an examination of adults in the United States and Taiwan. J Aging Health 27:75-102
Stephan, Yannick; Sutin, Angelina R; Terracciano, Antonio (2015) Subjective age and personality development: a 10-year study. J Pers 83:142-54
Sin, Nancy L; Graham-Engeland, Jennifer E; Almeida, David M (2015) Daily positive events and inflammation: findings from the National Study of Daily Experiences. Brain Behav Immun 43:130-8
Greenfield, Emily A; Reyes, Laurent (2015) Continuity and Change in Relationships with Neighbors: Implications for Psychological Well-being in Middle and Later Life. J Gerontol B Psychol Sci Soc Sci 70:607-18
Pudrovska, Tetyana (2015) Gender and health control beliefs among middle-aged and older adults. J Aging Health 27:284-303
Kivimäki, Mika; Virtanen, Marianna; Kawachi, Ichiro et al. (2015) Long working hours, socioeconomic status, and the risk of incident type 2 diabetes: a meta-analysis of published and unpublished data from 222?120 individuals. Lancet Diabetes Endocrinol 3:27-34
Kan, Chiemi; Kawakami, Norito; Karasawa, Mayumi et al. (2014) Psychological resources as mediators of the association between social class and health: comparative findings from Japan and the USA. Int J Behav Med 21:53-65
Luchetti, Martina; Barkley, James M; Stephan, Yannick et al. (2014) Five-factor model personality traits and inflammatory markers: new data and a meta-analysis. Psychoneuroendocrinology 50:181-93
Chung, Moo K; Kim, Seung-Goo; Schaefer, Stacey M et al. (2014) Improved Statistical Power with a Sparse Shape Model in Detecting an Aging Effect in the Hippocampus and Amygdala. Proc SPIE Int Soc Opt Eng 9034:90340Y
Curhan, Katherine B; Levine, Cynthia S; Markus, Hazel Rose et al. (2014) Subjective and Objective Hierarchies and Their Relations to Psychological Well-Being: A U.S/Japan Comparison. Soc Psychol Personal Sci 5:855-864

Showing the most recent 10 out of 195 publications