Core B builds on its extensive experience from the prior MIDUS project and will provide the resources and requisite expertise needed to collect and analyze all of the hematological, neuroendocrine, inflammatory and anti-oxidant indices, as well as the biochemical markers of bone turnover, for the proposed research. The BioCore already has the laboratory infrastructure and personnel skills to ensure the collection of reliable and comprehensive data through its centralized and high quality testing and record-keeping. The participant number and time line are in keeping with prior efforts and thus are essentially routine tasks for the BioCore. Specifically, Core B oversees the acquisition and processing of specimens from the regional sites, and either conducts the assays locally or oversees performance of the tests at the clinical laboratories. Our facility is also the initial repository for saliva samples used for assessing Cortisol and alpha-amylase levels, and is the primary liaison with the endocrine laboratory. Over 20,000 salivary specimens have already been processed in this manner. Finally, the BioCore has its own biochemical capabilities for analyses of cytokine levels, and the development of new procedues, and serves an archival function for the long-term storage of all urinary and serum/plasma specimens for the entire MIDUS program. In addition to facilitating the diagnostic testing, the Core is also responsible for the initial log entry of biological data into files of test results, and for resolving any queries or concerns about assay or test results. It oversees all aspects of quality assurance, including periodic Quality Control testing of assay reliability and determines the need for retesting of specimens. To facilitate the archival functions, the Core is the offical repository for all paper records on the hematological and neuroendocrine tests. The BioCore generates """"""""norms"""""""" for all test results, both from the MIDUS data as well as via reference to other studies and clinical laboratory values, and thereby also serves a consulting role with respect to the validity and interpretation of physiological findings. During the course ofthe prior MIDUS project, for example, it became evident that some of the standard approaches used for analyzing certain clinical test measures were in need of modification and improvement. In sum, the BioCore provides an efficient, economical, and reliable means for centralized and standardized assessment of biological measures from multiple sites. Through Core B all biological measures for this large national survey are determined in the same testing laboratories using the identical assays with routine Quality Control checks.
Inclusion of biomarkers and their reliable assessment overtime are critical components ofthe MIDUS project. One innovative feature of this project is the inclusion of so many biological measures in a population survey that also includes a comprehensive evaluation of demographic and psychosocial variables. The biomarker panel includes a representative set of well-validated measures associated with cardiovascular, metabolic, and bone health, as well as novel, cutting edge measures, such as urinary metabolomics.
|Stepanikova, Irena; Bateman, Lori Brand; Oates, Gabriela R (2017) Systemic Inflammation in Midlife: Race, Socioeconomic Status, and Perceived Discrimination. Am J Prev Med 52:S63-S76|
|Ransome, Yusuf; Slopen, Natalie; Karlsson, Oskar et al. (2017) The association between alcohol abuse and neuroendocrine system dysregulation: Race differences in a National sample. Brain Behav Immun 66:313-321|
|Barrett, Anne E; Toothman, Erica L (2017) Multiple ""Old Ages"": The Influence of Social Context on Women's Aging Anxiety. J Gerontol B Psychol Sci Soc Sci :|
|Wiley, Joshua F; Gruenewald, Tara L; Karlamangla, Arun S et al. (2017) The Authors Reply: Pursuing the Optimal Operationalization of Allostatic Load. Psychosom Med 79:119-121|
|Yoo, Jiah; Miyamoto, Yuri; Rigotti, Attilio et al. (2017) Linking Positive Affect to Blood Lipids: A Cultural Perspective. Psychol Sci 28:1468-1477|
|Tsenkova, Vera K (2017) Leisure-time, occupational, household physical activity and insulin resistance (HOMAIR) in the Midlife in the United States (MIDUS) national study of adults. Prev Med Rep 5:224-227|
|Priest, Jacob B (2017) Examining Differentiation of Self as a Mediator in the Biobehavioral Family Model. J Marital Fam Ther :|
|Boylan, Jennifer Morozink; Tsenkova, Vera K; Miyamoto, Yuri et al. (2017) Psychological resources and glucoregulation in Japanese adults: Findings from MIDJA. Health Psychol 36:449-457|
|Vittengl, J R (2017) Who pays the price for high neuroticism? Moderators of longitudinal risks for depression and anxiety. Psychol Med 47:1794-1805|
|Boylan, Jennifer Morozink; Robert, Stephanie A (2017) Neighborhood SES is particularly important to the cardiovascular health of low SES individuals. Soc Sci Med 188:60-68|
Showing the most recent 10 out of 499 publications