Core A. Administration. The Administrative Core will provide administrative support and services to the Program Director and each Investigator in the program. The Program Director is responsible for supervising the Program and coordinating interactions between the Investigators, and will need the assistance of this Core to carry out this function. Oversight and coordination of this Program will be achieved by several mechanisms including monthly program meetings, meetings with the program's advisory committee and inhouse presentations of our progress. The Core will also provide statistical support, arrange travel, coordinate arrangements for invited seminar speakers, arrange internal seminars and meetings, prepare Progress Reports and coordinate presentations among the Investigators and in outside forums. The function of coordinating meetings and data exchange is particularly crucial to achieving the goals of the program to develop a comprehensive understanding of the impact of aging on the immune response to infectious disease and our ultimate attempts to find strategies to overcome those defects.
Increased morbidity and mortality seen in elderly populations following influenza infection are thought to be due in large part to age-associated changes in the immune system. Thus, we need to better understand how age-related defects in the immune system contribute to reduced vaccine efficacy and if those defects can be overcome. This program examines the impact of age on T cell and humoral responses to influenza infection and vaccination. This Administrative Core will provide administrative support and services to the Program Director and each Investigator in the program.
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|Haynes, Laura; Swain, Susan L (2012) Aged-related shifts in T cell homeostasis lead to intrinsic T cell defects. Semin Immunol :|
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|Kohlmeier, Jacob E; Connor, Lisa M; Roberts, Alan D et al. (2010) Nonmalignant clonal expansions of memory CD8+ T cells that arise with age vary in their capacity to mount recall responses to infection. J Immunol 185:3456-62|
|Takamura, Shiki; Roberts, Alan D; Jelley-Gibbs, Dawn M et al. (2010) The route of priming influences the ability of respiratory virus-specific memory CD8+ T cells to be activated by residual antigen. J Exp Med 207:1153-60|
|Tsukamoto, Hirotake; Huston, Gail E; Dibble, John et al. (2010) Bim dictates naive CD4 T cell lifespan and the development of age-associated functional defects. J Immunol 185:4535-44|
|Maue, Alexander C; Eaton, Sheri M; Lanthier, Paula A et al. (2009) Proinflammatory adjuvants enhance the cognate helper activity of aged CD4 T cells. J Immunol 182:6129-35|
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