Aging is perhaps the most complex phenotype, and it is likely that there are multiple genetic and environmental contributors to longevity. Longevity-related data are challenging to analyze and require state of- the-art statistical methods. The primary activities of the Biostatistics and Bioinformatics Core (Core C) are to help with research conceptualization and planning, and support of statistical analyses. During the current funding period, the Biostatistics and Bioinformatics Core has provided advice and analytic support to investigators. Before-study consultation was provided to ensure appropriate design, and after-study statistical services included data analysis and consultation on interpretation of results. The core aided investigators in writing up their results, resulting in several collaborative manuscripts. The Biostatistics and Bioinformatics Core also developed the web-based database for the program investigators and utilized the database to facilitate interactions and interchange of research ideas among the investigators in order to foster new directions.
The specific aims of the Biostatistics and Bioinformatics Core are to: (1) coordinate and manage statistical activities in the overall program to ensure that investigators have ready access to statistical consultation and support;(2) provide statistical expertise for the design of new studies, including endpoint definition, sample size and power calculations, randomization procedures, data collection, plans for report generation, interim reviews, and final statistical analysis for all subprojects;(3) provide expertise in database development and management, develop data mining tools, and coordinate databases for data sharing among the projects/cores and with the scientific community;and (4) develop statistical approaches for novel experimental designs and statistical analyses. Methods to be developed will be, to the greatest extent possible, tailored to the needs of not only investigators involved in the overall program, but also the scientific community.

Public Health Relevance

The resistance of She knockout mice to obesity, diabetes and stress recommend them as model for healthy aging. The relevance of this core is to provide properly envisioned, well-designed and valid statistical analyses of properties of She knockout mice in order to translate their healthy features to the human condition.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program Projects (P01)
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Special Emphasis Panel (ZAG1-ZIJ-2)
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University of California Davis
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McMackin, Marissa Z; Henderson, Chelsea K; Cortopassi, Gino A (2017) Neurobehavioral deficits in the KIKO mouse model of Friedreich's ataxia. Behav Brain Res 316:183-188
Granatiero, Veronica; Gherardi, Gaia; Vianello, Matteo et al. (2017) Role of p66shc in skeletal muscle function. Sci Rep 7:6283
Song, Lanying; Yu, Alfred; Murray, Karl et al. (2017) Bipolar cell reduction precedes retinal ganglion neuron loss in a complex 1 knockout mouse model. Brain Res 1657:232-244
Taylor, Sandra L; Ruhaak, L Renee; Weiss, Robert H et al. (2017) Multivariate two-part statistics for analysis of correlated mass spectrometry data from multiple biological specimens. Bioinformatics 33:17-25
Roberts, Megan N; Wallace, Marita A; Tomilov, Alexey A et al. (2017) A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice. Cell Metab 26:539-546.e5
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Taylor, Sandra L; Ruhaak, L Renee; Kelly, Karen et al. (2017) Effects of imputation on correlation: implications for analysis of mass spectrometry data from multiple biological matrices. Brief Bioinform 18:312-320
Datta, Sandipan; Baudouin, Christophe; Brignole-Baudouin, Francoise et al. (2017) The Eye Drop Preservative Benzalkonium Chloride Potently Induces Mitochondrial Dysfunction and Preferentially Affects LHON Mutant Cells. Invest Ophthalmol Vis Sci 58:2406-2412
Hagopian, Kevork; Kim, Kyoungmi; López-Dominguez, José Alberto et al. (2016) Mice with low levels of Shc proteins display reduced glycolytic and increased gluconeogenic activities in liver. Biochem Biophys Rep 7:273-286
Datta, Sandipan; Tomilov, Alexey; Cortopassi, Gino (2016) Identification of small molecules that improve ATP synthesis defects conferred by Leber's hereditary optic neuropathy mutations. Mitochondrion 30:177-86

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