Abstract

The objectives of the Molecular Biology and Protein Purification Core will be to facilitate the timely production of highly purified proteins and plasmid preparations for the scientists in all projects in the Project. Specific functions of the Core will be to use well standardized protocols that produce materials of the highest quality for in vivo testing and in vitro testing in the gene vaccination studies. Because of the time consuming and technically demanding nature of these protocols, the goals of the current project can only be accomplished if all of these materials are produced from a central facility that is responsive to the needs of all of the individual projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI040682-02
Application #
6100132
Study Section
Project Start
1998-09-01
Project End
1999-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Lee, Jongdae; Abe, Kazumichi; Katakura, Kyoko et al. (2009) The protective effects of type-1 interferon in models of intestinal inflammation. Adv Exp Med Biol 633:1-6
Hayashi, Tomoko; Cottam, Howard B; Chan, Michael et al. (2008) Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7. Am J Physiol Regul Integr Comp Physiol 295:R123-32
Wu, Christina C N; Sabet, Mojgan; Hayashi, Tomoko et al. (2008) In vivo efficacy of a phosphodiester TLR-9 aptamer and its beneficial effect in a pulmonary anthrax infection model. Cell Immunol 251:78-85
Lee, Jongdae; Gonzales-Navajas, Jose M; Raz, Eyal (2008) The ""polarizing-tolerizing"" mechanism of intestinal epithelium: its relevance to colonic homeostasis. Semin Immunopathol 30:3-9
Lane, Nancy E; Nevitt, Michael C; Lui, Li-Yung et al. (2007) Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women. Arthritis Rheum 56:3319-25
Batzer, Glenda; Lam, Diane P; Paulus, Petra et al. (2007) Using house dust extracts to understand the immunostimulatory activities of living environments. Immunobiology 212:491-8
Hayashi, Tomoko; Mo, Ji-Hun; Gong, Xing et al. (2007) 3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis. Proc Natl Acad Sci U S A 104:18619-24
Abe, Kazumichi; Nguyen, Kim Phung; Fine, Sean D et al. (2007) Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells. Proc Natl Acad Sci U S A 104:17022-7
Raz, Eyal (2007) Organ-specific regulation of innate immunity. Nat Immunol 8:3-4
Wu, Christina C N; Hayashi, Tomoko; Takabayashi, Kenji et al. (2007) Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand. Proc Natl Acad Sci U S A 104:3990-5

Showing the most recent 10 out of 88 publications