Dr. Wucherpfennig has provided scientific and administrative leadership for this PPG since 1999, and this effort has been productive as evidenced by the large number of collaborative publications, many of which have been in high-impact journals. He will continue to closely interact with all members ofthe team to foster collaboration and identify new scientific opportunities. Dr. Wucherpfennig will organize regular formal scientific meetings at which recent progress will be presented and new opportunities for collaboration will be discussed. All project leaders work in the Boston area, Drs. Wucherpfennig, Turtey and Kuchroo on the Harvard Medical School (HMS) campus, and Dr. Love at the Koch Institute of MIT. Drs. Turley and Wucherpfennig are neighbors at the Dana-Farber Cancer Institute, and Drs. Kuchroo, Turtey and Wucherpfennig frequently meet at seminars and as part of the Program for Immunology at HMS. Drs. Kuchroo and Wucherpfennig also jointly teach an annual quarter course on Autoimmunity'for graduate students (since 1999). These frequent interactions foster dialogue and collaboration. In addition. Dr. Wucherpfennig will organize annual meetings with the Scientific Advisory Board (SAB) at which each project leader will present recent progress and discuss directions for the coming year. All members of our SAB work at HMS, and we will therefore also have many opportunities to consult them on an informal basis. Dr. Wucherpfennig will also continue to be in charge of all administrative aspects and will be assisted by this administrator and Dana-Farber grants and financial management specialists.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
2P01AI045757-15
Application #
8583041
Study Section
Special Emphasis Panel (ZAI1-MM-I (M1))
Project Start
2013-09-01
Project End
2018-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
15
Fiscal Year
2013
Total Cost
$35,286
Indirect Cost
$8,419
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
076580745
City
Boston
State
MA
Country
United States
Zip Code
02215
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Ponath, Gerald; Lincoln, Matthew R; Levine-Ritterman, Maya et al. (2018) Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis. Nat Commun 9:5337
Sumida, Tomokazu; Lincoln, Matthew R; Ukeje, Chinonso M et al. (2018) Activated ?-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity. Nat Immunol 19:1391-1402
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Kim, Yong Chan; Zhang, Ai-Hong; Yoon, Jeongheon et al. (2018) Engineered MBP-specific human Tregs ameliorate MOG-induced EAE through IL-2-triggered inhibition of effector T cells. J Autoimmun 92:77-86
Lucca, Liliana E; Hafler, David A (2017) Resisting fatal attraction: a glioma oncometabolite prevents CD8+ T cell recruitment. J Clin Invest 127:1218-1220
Nylander, Alyssa N; Ponath, Gerald D; Axisa, Pierre-Paul et al. (2017) Podoplanin is a negative regulator of Th17 inflammation. JCI Insight 2:
Gierahn, Todd M; Wadsworth 2nd, Marc H; Hughes, Travis K et al. (2017) Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput. Nat Methods 14:395-398

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