Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI046029-03
Application #
6500336
Study Section
Special Emphasis Panel (ZAI1)
Project Start
2001-09-01
Project End
2002-08-31
Budget Start
Budget End
Support Year
3
Fiscal Year
2001
Total Cost
Indirect Cost
City
Houston
State
TX
Country
United States
Zip Code
77225
Taguchi, Hiroaki; Keck, Zhenyong; Foung, Steven K H et al. (2004) Antibody light chain-catalyzed hydrolysis of a hepatitis C virus peptide. Bioorg Med Chem Lett 14:4529-32
Paul, Sudhir; Karle, Sangeeta; Planque, Stephanie et al. (2004) Naturally occurring proteolytic antibodies: selective immunoglobulin M-catalyzed hydrolysis of HIV gp120. J Biol Chem 279:39611-9
Karle, S; Nishiyama, Y; Taguchi, H et al. (2003) Carrier-dependent specificity of antibodies to a conserved peptide determinant of gp120. Vaccine 21:1213-8
Planque, Stephanie; Taguchi, Hiroaki; Burr, Gary et al. (2003) Broadly distributed chemical reactivity of natural antibodies expressed in coordination with specific antigen binding activity. J Biol Chem 278:20436-43
Paul, Sudhir; Planque, Stephanie; Zhou, Yong-Xin et al. (2003) Specific HIV gp120-cleaving antibodies induced by covalently reactive analog of gp120. J Biol Chem 278:20429-35
Bangale, Yogesh; Karle, Sangeeta; Planque, Stephanie et al. (2003) VIPase autoantibodies in Fas-defective mice and patients with autoimmune disease. FASEB J 17:628-35
Taguchi, Hiroaki; Burr, Gary; Karle, Sangeeta et al. (2002) A mechanism-based probe for gp120-Hydrolyzing antibodies. Bioorg Med Chem Lett 12:3167-70
Zhou, Yong-Xin; Karle, Sangeeta; Taguchi, Hiroaki et al. (2002) Prospects for immunotherapeutic proteolytic antibodies. J Immunol Methods 269:257-68
Nishiyama, Yasuhiro; Taguchi, Hiroaki; Luo, Jin-Quan et al. (2002) Covalent reactivity of phosphonate monophenyl esters with serine proteinases: an overlooked feature of presumed transition state analogs. Arch Biochem Biophys 402:281-8
Paul, S; Tramontano, A; Gololobov, G et al. (2001) Phosphonate ester probes for proteolytic antibodies. J Biol Chem 276:28314-20