The Administrative Core is directed by Dr. Dennis W. Metzger, Program Project Director. The Core Facility fosters completion of the research project specific aims, provides statistical analysis of data and supports effective interactions between the faculty and the supporting Core Facilities. This includes integration of the activities of each subproject to ensure effective and coordinated investigations into the mucosal immunopathogenesis of F. tularensis. The Core provides statistical analysis of experimental design and interpretation of results, administrative support, and fiscal management. An Executive Committee consisting of the Program Director and the subproject Project Leaders and Core Directors (Drs. Gosselin, Hazlett, Melendez, Metzger, and Sellati) meet twice monthly to review progress in the subprojects and to address any concerns or problems. An External Scientific Advisory Board, consisting of Drs. J. Wayne Conlan, Martha Furie, Lester Kobzik, Kathleen McDonough, and Anders Sjostedt, reviews results obtained in the subprojects and meets annually on site to review the program objectives and progress.

Public Health Relevance

This Core Facility will foster completion of the research project specific aims, provide statistical analysis of data and support effective interactions between the faculty and the supporting Core Facilities. This includes integration of the activities of each subproject to ensure effective and coordinated investigations.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program Projects (P01)
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Special Emphasis Panel (ZAI1)
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Albany Medical College
United States
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Chen, Fei; Cui, Guolin; Wang, Shuxia et al. (2017) Outer membrane vesicle-associated lipase FtlA enhances cellular invasion and virulence in Francisella tularensis LVS. Emerg Microbes Infect 6:e66
Periasamy, Sivakumar; Porter, Kristen A; Atianand, Maninjay K et al. (2017) Pyrin-only protein 2 limits inflammation but improves protection against bacteria. Nat Commun 8:15564
Holland, Kristen M; Rosa, Sarah J; Kristjansdottir, Kolbrun et al. (2017) Differential Growth of Francisella tularensis, Which Alters Expression of Virulence Factors, Dominant Antigens, and Surface-Carbohydrate Synthases, Governs the Apparent Virulence of Ft SchuS4 to Immunized Animals. Front Microbiol 8:1158
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Kumar, Sudeep; Sunagar, Raju; Pham, Giang et al. (2016) Differential Cultivation of Francisella tularensis Induces Changes in the Immune Response to and Protective Efficacy of Whole Cell-Based Inactivated Vaccines. Front Immunol 7:677
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