The Administrative Core is directed by Dr. Dennis W. Metzger, Program Project Director. The Core Facility fosters completion of the research project specific aims, provides statistical analysis of data and supports effective interactions between the faculty and the supporting Core Facilities. This includes integration of the activities of each subproject to ensure effective and coordinated investigations into the mucosal immunopathogenesis of F. tularensis. The Core provides statistical analysis of experimental design and interpretation of results, administrative support, and fiscal management. An Executive Committee consisting of the Program Director and the subproject Project Leaders and Core Directors (Drs. Gosselin, Hazlett, Melendez, Metzger, and Sellati) meet twice monthly to review progress in the subprojects and to address any concerns or problems. An External Scientific Advisory Board, consisting of Drs. J. Wayne Conlan, Martha Furie, Lester Kobzik, Kathleen McDonough, and Anders Sjostedt, reviews results obtained in the subprojects and meets annually on site to review the program objectives and progress.

Public Health Relevance

This Core Facility will foster completion of the research project specific aims, provide statistical analysis of data and support effective interactions between the faculty and the supporting Core Facilities. This includes integration of the activities of each subproject to ensure effective and coordinated investigations.

Agency
National Institute of Health (NIH)
Type
Research Program Projects (P01)
Project #
5P01AI056320-10
Application #
8711176
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Albany Medical College
Department
Type
DUNS #
City
Albany
State
NY
Country
United States
Zip Code
12208
Dixon, Ann M; Drake, Lisa; Hughes, Kelly T et al. (2014) Differential transmembrane domain GXXXG motif pairing impacts major histocompatibility complex (MHC) class II structure. J Biol Chem 289:11695-703
Pham, Giang H; Iglesias, Bibiana V; Gosselin, Edmund J (2014) Fc receptor-targeting of immunogen as a strategy for enhanced antigen loading, vaccination, and protection using intranasally administered antigen-pulsed dendritic cells. Vaccine 32:5212-20
Furuya, Yoichi; Wijesundara, Danushka K; Neeman, Teresa et al. (2014) Use and misuse of statistical significance in survival analyses. MBio 5:e00904-14
Ma, Zhuo; Banik, Sukalyani; Rane, Harshita et al. (2014) EmrA1 membrane fusion protein of Francisella tularensis LVS is required for resistance to oxidative stress, intramacrophage survival and virulence in mice. Mol Microbiol 91:976-95
Singh, Anju; Rahman, Tabassum; Malik, Meenakshi et al. (2013) Discordant results obtained with Francisella tularensis during in vitro and in vivo immunological studies are attributable to compromised bacterial structural integrity. PLoS One 8:e58513
Furuya, Yoichi; Kirimanjeswara, Girish S; Roberts, Sean et al. (2013) Increased susceptibility of IgA-deficient mice to pulmonary Francisella tularensis live vaccine strain infection. Infect Immun 81:3434-41
Mahawar, Manish; Rabadi, Seham M; Banik, Sukalyani et al. (2013) Identification of a live attenuated vaccine candidate for tularemia prophylaxis. PLoS One 8:e61539
Metzger, Dennis W; Salmon, Sharon L; Kirimanjeswara, Girish (2013) Differing effects of interleukin-10 on cutaneous and pulmonary Francisella tularensis live vaccine strain infection. Infect Immun 81:2022-7
Iglesias, Bibiana V; Bitsaktsis, Constantine; Pham, Giang et al. (2013) Multiple mechanisms mediate enhanced immunity generated by mAb-inactivated F. tularensis immunogen. Immunol Cell Biol 91:139-48
Dotson, Rachel J; Rabadi, Seham M; Westcott, Elizabeth L et al. (2013) Repression of inflammasome by Francisella tularensis during early stages of infection. J Biol Chem 288:23844-57

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