The Administrative Core (Core A) functions as the organizational structure that coordinates the activities of the Program Project Grant (POI) and facilitates its scientific mission. Core A will be co-directed by Drs. Brasier and Garofalo. The major goals of Core A are to assist the Project Leaders and Core Directors through the following five aims, to: 1. Promote Project Interactions and Synergy. Core A will coordinate twice-monthly research-in-progress meetings, conduct quarterly business meetings, promote inter-project communication and implement web-based networking for all four projects of this POI. Core A will also monitor and reallocate resources as necessary, and facilitate resolution of any conflicts that may arise during the conduct of these studies. 2. Provide Statistical Analysis and Data Management. Dr. Kristofer Jennings, a PhD-trained biostatistician, will collaborate with our projects on statistical aspects of experimental and clinical study design, power calculations, and data analysis for all of the individual projects of this POI. 3. Serve as the Single Point of Contact to the NIAID and UTMB Office of Sponsored Programs. Core A will be responsible for ensuring appropriate compliance, reporting, and fiscal management of the Projects and overall POI, including submitting the documentation and project reports required by the NIAID. 4. Coordinate POI External Reviews. Core A will facilitate 'site and reverse-site visits with the NIAID Project Officer, Internal Advisory Committee and External Advisory Committee meetings, facilitate their missions, and communicate their recommendations to the NIAID and POI Project Leaders. 5. Provide External Communications and Coordination of UTMB Asthma-related Research Initiatives. The co-Directors of Core A will ensure ongoing integration of the POI with other major research entities, including the UTMB Clinical and Translational Sciences Award, NHBLI Proteomics Center, and the Sealy Centers for Molecular Medicine and Environmental Health &Medicine, which have significantly advanced the goals of this POI. In this way. Core A interacts with all components of this POI, and will help the projects and cores to maintain continued progress towards their programmatic goals by relieving their leaders of burdensome administrative activities.

Public Health Relevance

Core A provides administrative and organizational support to all four Projects in this program. The relevance of this activity is to enable these scientific projects to more effectively perform their research and communicate their findings on how lung tissues respond to asthma-related stimuli.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI062885-07
Application #
8707688
Study Section
Allergy & Clinical Immunology-1 (AITC)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
7
Fiscal Year
2013
Total Cost
$67,964
Indirect Cost
$23,520
Name
University of Texas Medical Br Galveston
Department
Type
DUNS #
800771149
City
Galveston
State
TX
Country
United States
Zip Code
77555
Belanger, KarryAnne K; Ameredes, Bill T; Boldogh, Istvan et al. (2016) The Potential Role of 8-Oxoguanine DNA Glycosylase-Driven DNA Base Excision Repair in Exercise-Induced Asthma. Mediators Inflamm 2016:3762561
Hosoki, Koa; Itazawa, Toshiko; Boldogh, Istvan et al. (2016) Neutrophil recruitment by allergens contribute to allergic sensitization and allergic inflammation. Curr Opin Allergy Clin Immunol 16:45-50
Choudhary, Sanjeev; Boldogh, Istvan; Brasier, Allan R (2016) Inside-Out Signaling Pathways from Nuclear Reactive Oxygen Species Control Pulmonary Innate Immunity. J Innate Immun 8:143-55
Nicholson, Erin G; Schlegel, Chelsea; Garofalo, Roberto P et al. (2016) Robust Cytokine and Chemokine Response in Nasopharyngeal Secretions: Association With Decreased Severity in Children With Physician Diagnosed Bronchiolitis. J Infect Dis 214:649-55
German, Peter; Saenz, David; Szaniszlo, Peter et al. (2016) 8-Oxoguanine DNA glycosylase1-driven DNA repair-A paradoxical role in lung aging. Mech Ageing Dev :
Hosoki, Koa; Aguilera-Aguirre, Leopoldo; Brasier, Allan R et al. (2016) Facilitation of Allergic Sensitization and Allergic Airway Inflammation by Pollen-Induced Innate Neutrophil Recruitment. Am J Respir Cell Mol Biol 54:81-90
Ivanciuc, Teodora; Sbrana, Elena; Ansar, Maria et al. (2016) Hydrogen Sulfide Is an Antiviral and Antiinflammatory Endogenous Gasotransmitter in the Airways. Role in Respiratory Syncytial Virus Infection. Am J Respir Cell Mol Biol 55:684-696
Bacsi, Attila; Pan, Lang; Ba, Xueqing et al. (2016) Pathophysiology of bronchoconstriction: role of oxidatively damaged DNA repair. Curr Opin Allergy Clin Immunol 16:59-67
Chakraborty, Anirban; Tapryal, Nisha; Venkova, Tatiana et al. (2016) Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes. Nat Commun 7:13049
Hosoki, Koa; Boldogh, Istvan; Aguilera-Aguirre, Leopoldo et al. (2016) Myeloid differentiation protein 2 facilitates pollen- and cat dander-induced innate and allergic airway inflammation. J Allergy Clin Immunol 137:1506-1513.e2

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