The purpose of the Surgery Core (Core B) is to establish a focused facility to provide invesfigators in each of the three projects with a standardized source of kidney transplants to perform the experiments proposed. Core B will provide a key service role that will enable the Principle Invesfigators, their staff and the other scientific core to focus on experimental and scientific efforts. The provision of renal transplants from a centralized source will standardize the transplants and minimize surgically imposed disparifies in the grafts used by the three projects. The specific tasks of Core B will be to: a) perform renal transplants and recipient nephrectomy as directed by the project leaders and their personnel;b) to monitor the health of the renal transplant recipients and test for evidence of renal dysfunction;c) to assist the Program Director and the Project Leaders in preparation of progress reports, financial reports and manuscripts for publication; and, d) to assist the Program Director and the Project Leaders in preparation of lACUC applications.

Public Health Relevance

PROJECT/PERFORMANCE

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI087586-04
Application #
8470540
Study Section
Special Emphasis Panel (ZAI1-PTM-I)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
4
Fiscal Year
2013
Total Cost
$204,695
Indirect Cost
$74,316
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
135781701
City
Cleveland
State
OH
Country
United States
Zip Code
44195
Gorbacheva, V; Ayasoufi, K; Fan, R et al. (2015) B cell activating factor (BAFF) and a proliferation inducing ligand (APRIL) mediate CD40-independent help by memory CD4 T cells. Am J Transplant 15:346-57
Gorbacheva, Victoria; Fan, Ran; Wang, Xi et al. (2015) IFN-? production by memory helper T cells is required for CD40-independent alloantibody responses. J Immunol 194:1347-56
Ishii, Daisuke; Rosenblum, Joshua M; Nozaki, Taiji et al. (2014) Novel CD8 T cell alloreactivities in CCR5-deficient recipients of class II MHC disparate kidney grafts. J Immunol 193:3816-24
Abe, T; Su, C A; Iida, S et al. (2014) Graft-derived CCL2 increases graft injury during antibody-mediated rejection of cardiac allografts. Am J Transplant 14:1753-64
Gaughan, A; Wang, J; Pelletier, R P et al. (2014) Key role for CD4 T cells during mixed antibody-mediated rejection of renal allografts. Am J Transplant 14:284-94
Su, C A; Iida, S; Abe, T et al. (2014) Endogenous memory CD8 T cells directly mediate cardiac allograft rejection. Am J Transplant 14:568-79
Baldwin 3rd, William M; Su, Charles A; Shroka, Thomas M et al. (2014) Experimental models of cardiac transplantation: design determines relevance. Curr Opin Organ Transplant 19:525-30
Basu, Abhijit; Poddar, Darshana; Robinet, Peggy et al. (2014) Ribosomal protein L13a deficiency in macrophages promotes atherosclerosis by limiting translation control-dependent retardation of inflammation. Arterioscler Thromb Vasc Biol 34:533-42
Liu, Qiang; Nassar, Ahmed; Farias, Kevin et al. (2014) Sanguineous normothermic machine perfusion improves hemodynamics and biliary epithelial regeneration in donation after cardiac death porcine livers. Liver Transpl 20:987-99
Su, Charles A; Fairchild, Robert L (2014) Memory T Cells in Transplantation. Curr Transplant Rep 1:137-146

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