The purpose of the Surgery Core (Core B) is to establish a focused facility to provide invesfigators in each of the three projects with a standardized source of kidney transplants to perform the experiments proposed. Core B will provide a key service role that will enable the Principle Invesfigators, their staff and the other scientific core to focus on experimental and scientific efforts. The provision of renal transplants from a centralized source will standardize the transplants and minimize surgically imposed disparifies in the grafts used by the three projects. The specific tasks of Core B will be to: a) perform renal transplants and recipient nephrectomy as directed by the project leaders and their personnel;b) to monitor the health of the renal transplant recipients and test for evidence of renal dysfunction;c) to assist the Program Director and the Project Leaders in preparation of progress reports, financial reports and manuscripts for publication; and, d) to assist the Program Director and the Project Leaders in preparation of lACUC applications.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI087586-05
Application #
8664785
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
5
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
City
Cleveland
State
OH
Country
United States
Zip Code
44195
Baldwin 3rd, William M; Valujskikh, Anna; Fairchild, Robert L (2016) Mechanisms of antibody-mediated acute and chronic rejection of kidney allografts. Curr Opin Organ Transplant 21:7-14
Gorbacheva, Victoria; Fan, Ran; Fairchild, Robert L et al. (2016) Memory CD4 T Cells Induce Antibody-Mediated Rejection of Renal Allografts. J Am Soc Nephrol 27:3299-3307
Kohei, Naoki; Tanaka, Toshiaki; Tanabe, Kazunari et al. (2016) Natural killer cells play a critical role in mediating inflammation and graft failure during antibody-mediated rejection of kidney allografts. Kidney Int 89:1293-306
Iida, Shoichi; Tsuda, Hidetoshi; Tanaka, Toshiaki et al. (2016) IL-1 Receptor Signaling on Graft Parenchymal Cells Regulates Memory and De Novo Donor-Reactive CD8 T Cell Responses to Cardiac Allografts. J Immunol 196:2827-37
Baldwin 3rd, W M; Morelli, A E (2016) Strategically Altering the Balance of Macrophage Subpopulations to Inhibit Chronic Rejection. Am J Transplant 16:2510-1
Ayasoufi, Katayoun; Fan, Ran; Fairchild, Robert L et al. (2016) CD4 T Cell Help via B Cells Is Required for Lymphopenia-Induced CD8 T Cell Proliferation. J Immunol 196:3180-90
Gorbacheva, V; Ayasoufi, K; Fan, R et al. (2015) B cell activating factor (BAFF) and a proliferation inducing ligand (APRIL) mediate CD40-independent help by memory CD4 T cells. Am J Transplant 15:346-57
Kuo, Hsiao-Hsuan; Fan, Ran; Dvorina, Nina et al. (2015) Platelets in early antibody-mediated rejection of renal transplants. J Am Soc Nephrol 26:855-63
Valujskikh, Anna N (2015) B cells regulate antidonor T-cell reactivity in transplantation. Kidney Int 88:444-6
Gorbacheva, Victoria; Fan, Ran; Wang, Xi et al. (2015) IFN-γ production by memory helper T cells is required for CD40-independent alloantibody responses. J Immunol 194:1347-56

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