This Program Project Grant (PPG) is designed to explore the causal pathway from pet exposure to bacteria in the home and infant gastrointestinal tract, to immune development, to pediatric allergic asthma. The Biostatistics and Data Management Core (Core B) is critical to support the development and conduct of the four Projects in this PPG. Specifically, this Core will ensure the timely and accurate acquisition of data and its dispersion to the various Projects. The Core will provide a centralized database comprised of data collected for all Projects and Cores. A centralized database is an advantage when dealing with multiple sites, assuring the accurate linkage and confidentiality of all data types, along with ease of reporting on study progress. In addition, automated reports will be generated to enable the strict and regular monitoring of data activities by the PPG investigators. All data will undergo rigorous and regular data quality review. Further, secure and automated data transfer protocols will be developed and disseminated when necessary and where needed. This Core will also provide the resources to provide all investigators with data analyses needed to address their Specific Aims. The biostatistical expertise will ensure that all four Projects are efficiently and rigorously designed, conducted, monitored, and analyzed. The biostatisticians have a long history of collaboration with each other and with the investigators, resulting in funded grants and numerous publications. The Core will provide statistical methodological development and expertise to provide up-to-date statistical methods to design and analyze the various studies in the PPG. Biostatisticians will work regularly and directly with all investigators in the preparation of manuscripts and abstracts, ensuring rigorous analysis and interpretation of study data.

Public Health Relevance

Allergic diseases are a massive public health burden. This project will study the role of pet exposure, bacterial exposures and risk of allergy and atopic asthma. This Core will support the conduct of the proposed investigations and maintain a centralized, secure database, as well as provide statistical analyses of the data to support the conclusions of the studies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI089473-03
Application #
8843149
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Henry Ford Health System
Department
Type
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Wegienka, G; Havstad, S; Kim, H et al. (2017) Subgroup differences in the associations between dog exposure during the first year of life and early life allergic outcomes. Clin Exp Allergy 47:97-105
Cassidy-Bushrow, Andrea E; Sitarik, Alexandra R; Havstad, Suzanne et al. (2017) Burden of higher lead exposure in African-Americans starts in utero and persists into childhood. Environ Int 108:221-227
Sitarik, Alexandra R; Bobbitt, Kevin R; Havstad, Suzanne L et al. (2017) Breast Milk Transforming Growth Factor ? Is Associated With Neonatal Gut Microbial Composition. J Pediatr Gastroenterol Nutr 65:e60-e67
Havstad, Suzanne; Sitarik, Alexandra R; Johnson, Christine Cole et al. (2017) Allergic sensitization in American children of Middle Eastern ethnicity at age 2. Ann Allergy Asthma Immunol 119:464-466
Fonseca, W; Lucey, K; Jang, S et al. (2017) Lactobacillus johnsonii supplementation attenuates respiratory viral infection via metabolic reprogramming and immune cell modulation. Mucosal Immunol 10:1569-1580
Johnson, Christine C; Ownby, Dennis R (2017) The infant gut bacterial microbiota and risk of pediatric asthma and allergic diseases. Transl Res 179:60-70
Sitarik, Alexandra R; Bobbitt, Kevin R; Havstad, Suzanne L et al. (2017) Breast Milk TGF? is Associated with Neonatal Gut Microbial Composition. J Pediatr Gastroenterol Nutr :
Levin, Albert M; Sitarik, Alexandra R; Havstad, Suzanne L et al. (2016) Joint effects of pregnancy, sociocultural, and environmental factors on early life gut microbiome structure and diversity. Sci Rep 6:31775
Cassidy-Bushrow, Andrea E; Havstad, Suzanne; Basu, Niladri et al. (2016) Detectable Blood Lead Level and Body Size in Early Childhood. Biol Trace Elem Res 171:41-7
Lynch, Susan V; Boushey, Homer A (2016) The microbiome and development of allergic disease. Curr Opin Allergy Clin Immunol 16:165-71

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