Abstract

The Administrative Core will provide a coherent organizational structure for the project. It will coordinate the following activities: a. Financial management b. Administrative communication between institutions and between the project and NIH c. Scientific communication among investigators d. Decision making by the P01 leadership team e. Annual meeting of investigators with the External Scientific Advisory Board f. Management of IP issues g. Monitoring regulatory compliance

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
2P01AI089618-06
Application #
9209229
Study Section
Special Emphasis Panel (ZAI1)
Project Start
2011-08-01
Project End
2022-07-31
Budget Start
2017-06-01
Budget End
2018-05-31
Support Year
6
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
Boston Children's Hospital
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Finney, Joel; Yeh, Chen-Hao; Kelsoe, Garnett et al. (2018) Germinal center responses to complex antigens. Immunol Rev 284:42-50
McCarthy, Kevin R; Watanabe, Akiko; Kuraoka, Masayuki et al. (2018) Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires. Immunity 48:174-184.e9
Raymond, Donald D; Bajic, Goran; Ferdman, Jack et al. (2018) Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody. Proc Natl Acad Sci U S A 115:168-173
Ferdman, Jack; Palladino, Giuseppe; Liao, Hua-Xin et al. (2018) Intra-seasonal antibody repertoire analysis of a subject immunized with an MF59®-adjuvanted pandemic 2009 H1N1 vaccine. Vaccine 36:5325-5332
Finney, Joel; Kelsoe, Garnett (2018) Poly- and autoreactivity of HIV-1 bNAbs: implications for vaccine design. Retrovirology 15:53
Liu, Yuhang; Pan, Junhua; Jenni, Simon et al. (2017) CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody-Antigen Interface. J Mol Biol 429:1829-1839
Liu, Yuhang; Pan, Junhua; Cai, Yongfei et al. (2017) Conformational States of a Soluble, Uncleaved HIV-1 Envelope Trimer. J Virol 91:
Kuraoka, Masayuki; Schmidt, Aaron G; Nojima, Takuya et al. (2016) Complex Antigens Drive Permissive Clonal Selection in Germinal Centers. Immunity 44:542-552
Raymond, Donald D; Stewart, Shaun M; Lee, Jiwon et al. (2016) Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain. Nat Med 22:1465-1469
Lee, Jiwon; Boutz, Daniel R; Chromikova, Veronika et al. (2016) Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination. Nat Med 22:1456-1464

Showing the most recent 10 out of 18 publications