The objective of Core A is to administer different aspects of the Program and facilitate communication amongst the Cores and Projects. We envision three Specific Aims for the Administrative Core.
In Specific Aim 1, the Administrative core will facilitate communication between the Core and Project Leaders and all scientific and administrative personnel involved.
This aim defines the role of Core A In Data Management/Project Planning and Evaluation/Communication, Annual Retreat, and interactions with the Scientific Advisory Board. This will be done through biweekly, biannual and annual meetings, which will be easily archived given the proximity of the ail participants in the Program Project. Other interaction will be carried out by placing Information on the internet website we will create for this purpose. This Core will also organize an annual symposium that will be open to the public.
Specific Aim 2, encompasses scientific oversight and chain-of-command, fiscal management, clerical support, a publication plan, and materials transfer and project overiap.
Specific Aim 3, is to manage a fellowship funds program destined to enhance collaboration between the members of the Program and between the Program and scientists anywhere in the world. We will use funds to appoint three students or postdocs who will each jointly work with at least two groups. This innovative approach will facilitate a deeper collaborative effort merging expertise that is unique to each laboratory and allow specific labs to feel more comfortable venturing into new territory. We are also proposing to use these funds to allow scientists from Third World Countries to expend time working in the context of this Program Project. In this way we hope to create strong links with investigators in the field, which will enhance our investigations and get us closer to where novel solutions are needed. The Administrative Core is strategically positioned within the laboratory of Dr. Andino, Program Director, which will enhance the efficiency and effectiveness of the tasks performed by the Administrative Core. All financial, budgetary, personnel, and payroll records will be coordinated by the Administrative Core in close collaboration with administrative personnel in at the Department of Microbiology and Immunology and Office of Sponsored Programs at UCSF. Core A will report to all Program Project Grant participants electronically and will ensure that the output of this Program Project Grant will be greater than the sum of the outputs of the separate Cores and Projects.

Public Health Relevance

The goal of Core A is to provide a central resource for administering the program and to implement a management structure that will integrate and focus the scientific effort. This core will also ensure scientific and fiscal oversight, facilitate communication and data exchange between investigators, and administer research funds. It is also the responsibility of the core to organize biweekly meetings and annual retreats to monitor the progress of the project and foster our collaborative efforts.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-BB-M)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Francisco
San Francisco
United States
Zip Code
Davis, Zoe H; Verschueren, Erik; Jang, Gwendolyn M et al. (2015) Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes. Mol Cell 57:349-60
Stern, Adi; Bianco, Simone; Yeh, Ming Te et al. (2014) Costs and benefits of mutational robustness in RNA viruses. Cell Rep 8:1026-36
Acevedo, Ashley; Andino, Raul (2014) Library preparation for highly accurate population sequencing of RNA viruses. Nat Protoc 9:1760-9
Morris, John H; Knudsen, Giselle M; Verschueren, Erik et al. (2014) Affinity purification-mass spectrometry and network analysis to understand protein-protein interactions. Nat Protoc 9:2539-54
Acevedo, Ashley; Brodsky, Leonid; Andino, Raul (2014) Mutational and fitness landscapes of an RNA virus revealed through population sequencing. Nature 505:686-90
Hagai, Tzachi; Azia, Ariel; Babu, M Madan et al. (2014) Use of host-like peptide motifs in viral proteins is a prevalent strategy in host-virus interactions. Cell Rep 7:1729-39
Pechmann, Sebastian; Frydman, Judith (2014) Interplay between chaperones and protein disorder promotes the evolution of protein networks. PLoS Comput Biol 10:e1003674
Fraser, James S; Gross, John D; Krogan, Nevan J (2013) From systems to structure: bridging networks and mechanism. Mol Cell 49:222-31
Geller, Ron; Andino, Raul; Frydman, Judith (2013) Hsp90 inhibitors exhibit resistance-free antiviral activity against respiratory syncytial virus. PLoS One 8:e56762
Roguev, Assen; Talbot, Dale; Negri, Gian Luca et al. (2013) Quantitative genetic-interaction mapping in mammalian cells. Nat Methods 10:432-7

Showing the most recent 10 out of 17 publications