The objective of Core A is to administer different aspects of the Program and facilitate communication amongst the Cores and Projects. We envision three Specific Aims for the Administrative Core.
In Specific Aim 1, the Administrative core will facilitate communication between the Core and Project Leaders and all scientific and administrative personnel involved.
This aim defines the role of Core A In Data Management/Project Planning and Evaluation/Communication, Annual Retreat, and interactions with the Scientific Advisory Board. This will be done through biweekly, biannual and annual meetings, which will be easily archived given the proximity of the ail participants in the Program Project. Other interaction will be carried out by placing Information on the internet website we will create for this purpose. This Core will also organize an annual symposium that will be open to the public.
Specific Aim 2, encompasses scientific oversight and chain-of-command, fiscal management, clerical support, a publication plan, and materials transfer and project overiap.
Specific Aim 3, is to manage a fellowship funds program destined to enhance collaboration between the members of the Program and between the Program and scientists anywhere in the world. We will use funds to appoint three students or postdocs who will each jointly work with at least two groups. This innovative approach will facilitate a deeper collaborative effort merging expertise that is unique to each laboratory and allow specific labs to feel more comfortable venturing into new territory. We are also proposing to use these funds to allow scientists from Third World Countries to expend time working in the context of this Program Project. In this way we hope to create strong links with investigators in the field, which will enhance our investigations and get us closer to where novel solutions are needed. The Administrative Core is strategically positioned within the laboratory of Dr. Andino, Program Director, which will enhance the efficiency and effectiveness of the tasks performed by the Administrative Core. All financial, budgetary, personnel, and payroll records will be coordinated by the Administrative Core in close collaboration with administrative personnel in at the Department of Microbiology and Immunology and Office of Sponsored Programs at UCSF. Core A will report to all Program Project Grant participants electronically and will ensure that the output of this Program Project Grant will be greater than the sum of the outputs of the separate Cores and Projects.

Public Health Relevance

The goal of Core A is to provide a central resource for administering the program and to implement a management structure that will integrate and focus the scientific effort. This core will also ensure scientific and fiscal oversight, facilitate communication and data exchange between investigators, and administer research funds. It is also the responsibility of the core to organize biweekly meetings and annual retreats to monitor the progress of the project and foster our collaborative efforts.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program Projects (P01)
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Special Emphasis Panel (ZAI1-BB-M)
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University of California San Francisco
San Francisco
United States
Zip Code
Xiao, Yinghong; Rouzine, Igor M; Bianco, Simone et al. (2016) RNA Recombination Enhances Adaptability and Is Required for Virus Spread and Virulence. Cell Host Microbe 19:493-503
Webb, Benjamin; Sali, Andrej (2016) Comparative Protein Structure Modeling Using MODELLER. Curr Protoc Bioinformatics 54:5.6.1-5.6.37
Cimermancic, Peter; Weinkam, Patrick; Rettenmaier, T Justin et al. (2016) CryptoSite: Expanding the Druggable Proteome by Characterization and Prediction of Cryptic Binding Sites. J Mol Biol 428:709-19
Whitfield, Zachary J; Andino, Raul (2016) Characterization of Viral Populations by Using Circular Sequencing. J Virol 90:8950-3
Verschueren, Erik; Von Dollen, John; Cimermancic, Peter et al. (2015) Scoring Large-Scale Affinity Purification Mass Spectrometry Datasets with MiST. Curr Protoc Bioinformatics 49:8.19.1-16
Ramage, Holly R; Kumar, G Renuka; Verschueren, Erik et al. (2015) A combined proteomics/genomics approach links hepatitis C virus infection with nonsense-mediated mRNA decay. Mol Cell 57:329-40
Davis, Zoe H; Verschueren, Erik; Jang, Gwendolyn M et al. (2015) Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes. Mol Cell 57:349-60
Schulte, Michael B; Draghi, Jeremy A; Plotkin, Joshua B et al. (2015) Experimentally guided models reveal replication principles that shape the mutation distribution of RNA viruses. Elife 4:
Costa, Helio A; Leitner, Michael G; Sos, Martin L et al. (2015) Discovery and functional characterization of a neomorphic PTEN mutation. Proc Natl Acad Sci U S A 112:13976-81
Shah, Priya S; Wojcechowskyj, Jason A; Eckhardt, Manon et al. (2015) Comparative mapping of host-pathogen protein-protein interactions. Curr Opin Microbiol 27:62-8

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