An administrative core (Core A) is requested in this proposal to facilitate institutional and investigator interactions at three universities (MIT, UCB, UCSF) and involving five investigators (Drs. Chakraborty, Groves, Kuriyan, Roose and Weiss). The budgets, fund distribution, reconciliation, and progress report preparation will be coordinated at UCSF where Dr. Weiss is located with the assistance of a research analyst. Such efforts will take time and demand a great deal of additional coordination and effort. A part time effort (25% or 3 calendar months) of an administrative assistant will help facilitate communication between investigators, postdoctoral fellows, students and staff. This will include but not be limited to scheduling regular SKYPE video meetings and conference calls, distributing data and research communications, maintaining a web site, and setting up onsite meetings (at UCSF or UCB). We anticipate that Dr. Chakraborty and his team will travel to the Bay area twice a year for meetings of all investigators and their groups.

Public Health Relevance

Due to the complexity of the program project, involving 5 investigators and 3 institutions, it is necessary to ensure proper funds flow, distribution and reporting. In addition, facilitating communication across large distances needs to be facilitated and coordinated. The administrative core A will provide this coordination and improve efficiencies of these processes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI091580-03
Application #
8503588
Study Section
Special Emphasis Panel (ZAI1-RRS-I)
Project Start
2013-07-01
Project End
2016-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
3
Fiscal Year
2013
Total Cost
$42,744
Indirect Cost
$6,371
Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Christensen, Sune M; Tu, Hsiung-Lin; Jun, Jesse E et al. (2016) One-way membrane trafficking of SOS in receptor-triggered Ras activation. Nat Struct Mol Biol 23:838-46
Thill, Peter A; Weiss, Arthur; Chakraborty, Arup K (2016) Phosphorylation of a Tyrosine Residue on Zap70 by Lck and Its Subsequent Binding via an SH2 Domain May Be a Key Gatekeeper of T Cell Receptor Signaling In Vivo. Mol Cell Biol 36:2396-402
Chen, Hang; Thill, Peter; Cao, Jianshu (2016) Transitions in genetic toggle switches driven by dynamic disorder in rate coefficients. J Chem Phys 144:175104
Rooney, Gemma E; Goodwin, Alice F; Depeille, Philippe et al. (2016) Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome. J Neurosci 36:142-52
Chan, Alice Y; Punwani, Divya; Kadlecek, Theresa A et al. (2016) A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70. J Exp Med 213:155-65
Huang, William Y C; Yan, Qingrong; Lin, Wan-Chen et al. (2016) Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS. Proc Natl Acad Sci U S A 113:8218-23
Chung, Jean K; Lee, Young Kwang; Lam, Hiu Yue Monatrice et al. (2016) Covalent Ras Dimerization on Membrane Surfaces through Photosensitized Oxidation. J Am Chem Soc 138:1800-3
Ashouri, Judith F; Weiss, Arthur (2016) Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells. J Immunol :
Christensen, Sune M; Triplet, Meredith G; Rhodes, Christopher et al. (2016) Monitoring the Waiting Time Sequence of Single Ras GTPase Activation Events Using Liposome Functionalized Zero-Mode Waveguides. Nano Lett 16:2890-5
Shah, Neel H; Wang, Qi; Yan, Qingrong et al. (2016) An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor. Elife 5:

Showing the most recent 10 out of 50 publications