Behavioral Function - Core C Individuals surviving sepsis exhibit impaired cognitive function. We are modeling this process in mice. The Behavioral Function Core will subject mice to a battery of assessments of neurologic function including behavioral and cognitive tasks. In addition, the Core will assess long term potentiation in brain slices of mice. The use of a Core facility for these studies will ensure the involvement of trained personnel, standardized procedures, and standardized data analyses and so will facilitate comparability across all, projects. All Core personnel will have undergone the same training so all mice will be exposed to the same test, as well non test, stimuli.
|Huerta, Patricio T; Robbiati, Sergio; Huerta, TomÃ¡s Salvador et al. (2016) Preclinical models of overwhelming sepsis implicate the neural system that encodes contextual fear memory. Mol Med 22:|
|Chang, Eric H; Volpe, Bruce T; Mackay, Meggan et al. (2015) Selective Impairment of Spatial Cognition Caused by Autoantibodies to the N-Methyl-d-Aspartate Receptor. EBioMedicine 2:755-64|
|Brimberg, Lior; Mader, Simone; Fujieda, Yuichiro et al. (2015) Antibodies as Mediators of Brain Pathology. Trends Immunol 36:709-24|
|Volpe, Bruce T; Berlin, Rose Ann; Frankfurt, Maya (2015) The brain at risk: the sepsis syndrome and lessons from preclinical experiments. Immunol Res 63:70-4|
|ValdÃ©s-Ferrer, Sergio I; Papoin, Julien; Dancho, Meghan E et al. (2015) HMGB1 mediates anemia of inflammation in murine sepsis survivors. Mol Med :|
|Huerta, Patricio T; Gibson, Elizabeth L; Rey, Carson et al. (2015) Integrative neuroscience approach to neuropsychiatric lupus. Immunol Res 63:11-7|