Animal Model Reagent, and Immune Function - Core B Severe sepsis is a major public health problem, because it is the leading cause of death in hospitalized patients in the United States, and one of the ten leading causes of death in the developed world. Seventy percent of the sepsis patients survive, but often do not return to their premorbid condition. Recent evidence indicates that sepsis survivors experience cognitive and immune impairment, and more than half of the survivors die within 5 years. The Animal, Reagent and Immune Function Core will provide a centralized resource for performing animal surgeries, generating cytokine and antibody reagents, and overseeing immune function assessment tests. Use of these animal models and reagents in studies proposed here will provide significant data that can be used to modulate neural and immune function to develop therapeutic modalities for the prevention and treatment of sepsis induced cognitive and immune impairments.
; This Core will help in mouse surgery and in tests of immune function. It will produce cytokines and antibodies for all research projects.
| Kim, Sook Young; Son, Myoungsun; Lee, Sang Eun et al. (2018) High-Mobility Group Box 1-Induced Complement Activation Causes Sterile Inflammation. Front Immunol 9:705 |
| Pavlov, Valentin A; Chavan, Sangeeta S; Tracey, Kevin J (2018) Molecular and Functional Neuroscience in Immunity. Annu Rev Immunol 36:783-812 |
| Li, Wei; Bao, Guoqiang; Chen, Weiqiang et al. (2018) Connexin 43 Hemichannel as a Novel Mediator of Sterile and Infectious Inflammatory Diseases. Sci Rep 8:166 |
| Gunasekaran, Manojkumar; Chatterjee, Prodyot K; Shih, Andrew et al. (2018) Immunization Elicits Antigen-Specific Antibody Sequestration in Dorsal Root Ganglia Sensory Neurons. Front Immunol 9:638 |
| Zanos, Theodoros P; Silverman, Harold A; Levy, Todd et al. (2018) Identification of cytokine-specific sensory neural signals by decoding murine vagus nerve activity. Proc Natl Acad Sci U S A 115:E4843-E4852 |
| Chavan, Sangeeta S; Ma, Pingchuan; Chiu, Isaac M (2018) Neuro-immune interactions in inflammation and host defense: Implications for transplantation. Am J Transplant 18:556-563 |
| Rana, Minakshi; Fei-Bloom, Yurong; Son, Myoungsun et al. (2018) Constitutive Vagus Nerve Activation Modulates Immune Suppression in Sepsis Survivors. Front Immunol 9:2032 |
| Zaghloul, Nahla; Addorisio, Meghan E; Silverman, Harold A et al. (2017) Forebrain Cholinergic Dysfunction and Systemic and Brain Inflammation in Murine Sepsis Survivors. Front Immunol 8:1673 |
| Hirano, Yohei; Yang, Weng-Lang; Aziz, Monowar et al. (2017) MFG-E8-derived peptide attenuates adhesion and migration of immune cells to endothelial cells. J Leukoc Biol 101:1201-1209 |
| Chavan, Sangeeta S; Pavlov, Valentin A; Tracey, Kevin J (2017) Mechanisms and Therapeutic Relevance of Neuro-immune Communication. Immunity 46:927-942 |
Showing the most recent 10 out of 26 publications
